Introduction and expression of foreign genetic material in epith

Details Introduction and expression of foreign genetic material in epith Introduction and expression of foreign genetic material in epith

1995-06-06

1997-12-16

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4351723, 424 9321, C12N 1585, C12N 1556, C12N 1500

Patent

active

056984367

ABSTRACT:
Epithelial cells expressing foreign genetic material are described. The foreign genetic material can be DNA or RNA which does not occur in epithelial cells; DNA or RNA which occurs in epithelial cells but is not expressed in them at levels which are biologically significant; DNA or RNA which occurs in epithelial and has been modified so that it is expressed in epithelial cells; and any DNA or RNA which can be modified to be expressed in epithelial cells, alone or in any combination thereof. In addition, epithelial cells of the present invention can express genetic material encoding a selectable marker by which cells expressing the foreign genetic material can be expressed.

REFERENCES:
patent: 4016036 (1977-04-01), Green et al.
patent: 4304866 (1981-12-01), Green et al.
patent: 4769317 (1988-09-01), Hefton
patent: 4980286 (1990-12-01), Morgan et al.
patent: 5399346 (1995-03-01), Anderson et al.
Owen et al. "Cloned Mouse Mammary Tumor Virus DNA Exhibits Glucocorticoid-Dependent Expression in Simian Virus 40-Transformed Mink Cells", Journal of Virology, vol. 45, No. 1, pp. 148-154, Jan. 1983.
H. Kobayashi and F. Sendo, 1979, "Immunogenicity of Viable Xenogenized Tumor Cells," GANN Monograph on Cancer Research 23:27-39.
H. Kobayashi, F. Sendo et al., 1969, "Modification in Growth of Transplantable Rat Tumor Exposed to Friend Virus," J. Nat. Cancer Institute 42:413-419.
Y. Shimizu, H. Fujiwara et al., 1984, "The augmentation of tumor-specific immunity by virus help, II, Enhanced iduction of cytotoxic T Lymphocyte and antibody response to tumor antigens by vaccinia virus-reactive helper T cells," Eur. J. Immunol. 14:839-843.
R.D. Cone, and R.C. Mulligan, 1984, "High-efficiency gene transfer into mammalian cells; Generation of helper-free recombinant retrovirus with broad mammalian host range," Proc. Natl. Acad. Sci. U.S.A. 81:6349-6353.
E. Gilboa, P. Kantoff et al., 1985, "Use of retrovirus derived vectors in somatic gene therapy: The human adenin deaminase (ADA) deficiency system," Abstract of papers presented at the 1985 Meeting RNA Tumor Viruses Cold Spring Harbor Laboratory New York 314.
W.F. Anderson, 1984, "Prospects for Human Gene Therapy," Science 226:410-409.
D.W. Fawcett, 1986, A Textbook of Histology, W.B. Saunders Company, Philadelphia, London, Toronto, Mexico City, Rio de Janeiro, Sydney, Tokyo, Hong Kong, S. -57-59.
B. Alberts, D. Bray et al., 1983, Molecular Biology of the Cell Garland Publishing, Inc., New York & London S.942-945.
R.J. Woods, B.J. Fuller et al., 1982, "Functional Assessment of Hepatocytes After Transplantation Into Rat Spleen," Transplantation 33:123-126.
N. Ferry, O. Duplessis et al., 1991, "Retroviral-mediated gene transfer into Hepatocytes in vivo," Proc. Natl. Acad. Sci. U.S.A. 88:8377-8381.
K. Parker Ponder, S. Gupta et al., 1991, "Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation," Proc. Natl. Acad. Sci. U.S.A. 88:1217-1221.
J.M. Wilson, D.M. Jefferson et al., 1988, "Retrovirus-mediated transduction of adult hepatocytes," Proc. Natl. Acad. Sci. U.S.A. 85:3014-3018.
A.A. Dematriou, J.F. Whiting et al., 1986, "Replacement of liver function in rats by transplantation of microcarrier-attached hepatocytes," Science 233:1190-1192.
J.M. Wilson, L.K. Birinyi et al., 1989, "Implantation of Vascular Grafts Lined with Genetically Modified Endothelial Cells," Science 244:1344-1346.
Miller et al., 1984, Science 225:993-998.
Stuhlman et al., 1984, Proc. Natl. Acad. Sci. U.S.A. 81:7151-7155.
Williams et al., 1984, Nature 310:476-480.
Green et al., 1979, Proc. Natl. Acad. Sci. U.S.A. 76:5665-5668.
O'Connor et al., 1981, The Lancet 75-81.
Hynes et al., 1985, Mol. and Cell. Biol. 5:268-272.
Roth et al., 1983, Cell 33:435-443.
Allen-Hoffman & Reinwald, 1984, Proc. Natl. Acad. Sci. U.S.A. 81:7802-7806.
R. C. Mulligan, 1993, Science 260:926-932.
I.M. Leigh et al., 1991, Ann. Acad. Med. Singaport 20(4):549-555.

Affiliated with

Also associated with

Rating

Introduction and expression of foreign genetic material in epith does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Introduction and expression of foreign genetic material in epith, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Introduction and expression of foreign genetic material in epith will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-205086