Intravesical drug delivery system

Details Intravesical drug delivery system Intravesical drug delivery system

1998-04-02

2000-03-21

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424430, 5147723, A61F 202, A61F 606, A61K 4730

Patent

active

060399678

ABSTRACT:
Bioerodible, sustained release preparations are provided for placement into the bladder through the urethra which provide sustained release of drugs. Configurations are provided which are insertable through a catheter, such as a coiled filament, patch or a flowable gel. The device is bioeroded during or after the sustained release of the drug such that there is no blockage of the urinary tract while the device is in place within the bladder.

REFERENCES:
patent: 5021241 (1991-06-01), Yamahira et al.
patent: 5326761 (1994-07-01), Rozier
Ekstroom, B., et al., "Intravesical instillation of drugs in patients with detrusor hyperactivity," Depts. of Urology and clinical Pharmacology, University Hospital, Lund, Sweden, pp. 11-67.
Massad, C. A., et al., "The Pharmacokinetics of Intravesical and Oral Oxybutynin Chloride," J. Urol. 148:595-597.
Okado, M., et al., "Study of Intravesical Stick (Part I): Method of Preparation and dissolution Test for Active Component," Yakugaku Zasshi, 105(10): 1001-1003.
Okado, M., et al., "Study of Intravesical Stick (Part I): Development of Intravesical Stick, and Manufacture of Instillator," Nichihitsunyokaishi, 76(2): 197-203.

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