Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure – Having a known elemental analysis
Patent
1979-08-15
1981-02-17
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Fermentate of unknown chemical structure
Having a known elemental analysis
424177, 260112B, A61K 3514, A61K 3700, C07G 700
Patent
active
042515106
ABSTRACT:
Plasma Protein Fraction substantially free of bradykinin, kininogen and prekallikrein activators is obtained by treating Cohn Supernatant II plus III at about neutrality with a siliceous substance for a period of time sufficient to bring about essentially complete conversion of intrinsic kininogen into bradykinin. Subsequently, after being separated from Cohn Fraction IV-1, the Plasma Protein Fraction is reconstituted and held for a period of time sufficient to allow substantially complete destruction of bradykinin by kininase. Methods are disclosed for the destruction of prekallikrein activators which may be present in Plasma Protein Fraction.
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Margolis, Thromb. Diath. Haemor., Suppl. 4, 132-136 (1959).
Soulur, Thromb. Diath. Haemor., Suppl. 4, 137-141 (1959).
Allen Robert E.
Cutter Laboratories, Inc.
Leitereg Theodore J.
Phillips Delbert R.
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