Intravenously administerable polyclonal immunoglobulin preparati

Details Intravenously administerable polyclonal immunoglobulin preparati Intravenously administerable polyclonal immunoglobulin preparati

1989-07-14

1993-03-02

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Lymphokine

5303871, 530416, 530417, 530421, A61K 39395, C07K 312, C07K 324, C07K 328

Patent

active

051907526

ABSTRACT:
An intravenously administrable polyclonal immunoglobulin preparation for the treatment and prophylaxis of bacterial infections containing at least 50% by weight of IgM in terms of the total content of immunoglobulin, exhibiting a low anticomplementary activity, being stable in aqueous solution, and being free of viruses. It can also consist of or also contain a mixture of several monoclonal IgM antibodies. The source material for its manufacture is an immunoglobulin-containing fraction of human, animal, or bacterial provenance. The fraction is treated with an anion exchanger that is eluted with a saline or pH gradient and the eluate is optionally subjected to gel filtration, treated before or after the chromatography with .beta.-propiolactone and PEG 4000, and optionally heated. Treatment with .beta.-propiolactone and ultraviolet light, treatment with solvents and detergents, or pasteurization can also be conducted. Proteins, sugars, or mixtures of amino acids are optionally added to the preparation.

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