Intravenous plasma derivatives and their production

Details Intravenous plasma derivatives and their production Intravenous plasma derivatives and their production

1980-06-13

1981-12-15

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424101, C07G 700

Patent

active

043058701

ABSTRACT:
Intravenous plasma derivatives having an acceptably lowered content of externally caused deleterious activity or exogenous activity, and their method of production are provided. The method includes the steps of mixing bentonite and an aqueous solution of plasma derivative containing exogenous activity, the bentonite and the mixing time being sufficient to adsorb exogenous activity, and isolating the aqueous phase from the bentonite. Optionally, for the removal of residual exogenous activity, the step of treatment of the aqueous phase with bentonite is repeated and/or the bentonite-treated aqueous phase is further purified by ion-exchange chromatography.

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patent: 3466368 (1969-09-01), Sela et al.
patent: 3664994 (1972-05-01), Perper
patent: 3674863 (1972-07-01), Fisher et al.
patent: 3869436 (1975-03-01), Falksveden
patent: 4100149 (1978-07-01), Meiller et al.
patent: 4136094 (1979-01-01), Condie
Alving et al., New England J. Med. 299, 66-70 (1978).

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