Intravenous administration of psoralen

Chemistry: molecular biology and microbiology – Maintaining blood or sperm in a physiologically active state...

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4351733, 424532, A01N 102, C12N 1300, A61K 3514

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active

056186622

ABSTRACT:
Intravenous administration of 8-methoxypsoralen is disclosed, and more specifically intravenous administration of 8-methoxypsoralen-blood preparations, including platelets. Random donor platelet bags are treated, stored and pooled prior to transfusion.

REFERENCES:
patent: Re32874 (1989-02-01), Rock et al.
patent: 4124598 (1978-11-01), Hearst et al.
patent: 4157723 (1979-06-01), Granzow et al.
patent: 4169204 (1979-09-01), Hearst et al.
patent: 4196281 (1980-04-01), Hearst et al.
patent: 4265280 (1981-05-01), Ammann et al.
patent: 4390619 (1983-06-01), Harmening-Pittiglio
patent: 4412835 (1983-11-01), Spencer
patent: 4447415 (1984-05-01), Rock
patent: 4695460 (1987-09-01), Holme
patent: 4704352 (1987-11-01), Miripol et al.
patent: 4727027 (1988-02-01), Wiesehahn
patent: 4748120 (1988-05-01), Wiesehahn
patent: 4828976 (1989-05-01), Murphy
patent: 4878891 (1989-11-01), Judy et al.
patent: 4925665 (1990-05-01), Murphy
patent: 4960408 (1990-10-01), Klainer
patent: 4992363 (1991-02-01), Murphy
patent: 5288605 (1994-02-01), Lin
Lin L., Use of 8-Mop & Long Wavelength UV Radiation . . . Blood vol. 74 No. 1 Jul. 1989 pp. 517-525.
Knobler R., Parenteral Administration of 8-Mop in Photopheresis, J Am Acad Dermatology, 28 (4) Apr. 1993 pp. 580-584.
Murphy and Gardner, "Effect of Storage Temperature on Maintenance of Platelet Viability--Deleterious Effect on Refrigerated Storage," New Eng. J. Med. 280:1094 (1969).
B.J. Grossman et al., "Screening blood donors for gastrointestinal illness: a strategy to eliminate carriers of Yersinia enterocolitica," Transfusion 31:500 (1991).
B.A. Myhre, "Fatalities from Blood Transfusion," JAMA 244:1333 (1980).
J.M. Heal et al., "Fatal Salmonella septicemia after platelet transfusion," Transfusion 27:1 (1987).
D.H. Buchholz, et al., "Detection and Quantitation of Bacteria in Platelet Products Stored at Ambient Temperature," Transfusion 13:268 (1973).
D.H. Buchholz, et al., "Bacterial Proliferation in Platelet Products Stored at Room Temperature," New Eng. J. Med. 285:429 (1971).
J. F. Morrow et al., "Septic Reactions to Platelet Transfusions," JAMA 266:555 (1991).
G. D. Cimino et al., "Psoralens as Photoactive Probes of Nucleic Acid Structure and Function: Organic Chemistry, Photochemistry, and Biochemistry," Ann. Rev. Biochem. 54:1151 (1985).
Hearst et al., "The reaction of the psoralens with deoxyribonucleic acid," Quart. Rev. Biophys. 17:1 (1984).
S.T. Isaacs et al., "Synthesis and Characterization of New Psoralen Derivatives with Superior Photoreactivity with DNA and RNA," Biochemistry 16:1058 (1977).
S.T. Isaacs et al., "A Photochemical Characterization of Reactions of Psoralen Derivatives with DNA," Trends in Photology (Plenum) pp. 279 94 (1982).
J. Tessman et al., "Photochemistry of the Furan-Side 8-Methoxypsoralen-Thymidine Monoadduct Inside the DNA Helix. Conversion to Diadduct and to Pyrone-Side Monoadduct," Biochem. 24:1669 (1985).
H.J. Alter et al., "Photochemical Decontamination of Blood Components Containing Hepatitis B and non-A, Non-B Virus," The Lancet (ii:1446) (1988).
L. Lin et al., "Use of 8-Methoxypsoralen and Long-Wavelength Ultraviolet Radiation for Decontamination of Platelet Concentrates," Blood 74:517 (1989).
Hyde and Hearst, "Binding of Psoralen Derivatives to DNA and Chromatin: Influence of the Ionic Environment on Dark Binding and Photoreactivity," Biochemistry 17:1251 (1978).
Thompson et al., "Determination of the Secondary Structure of Drosphila Melanogaster 5 S RNA by Hydroxymethyltrimethylpsoralen Crosslinking," J. Mol. Biol. 147:417 (1981).
Thompson et al., "Dependence of 4'-(Hydroxymethyl)-4,5',8-trimethylpsoralen Photoaddition on the Conformation of Ribonucleic Acid," Biochemistry 21:1363 (1982).
P.A. Ristuccia and B.A. Cunha, "Klebsiella," Infect. Control 5:343 (1984).
M. Artuc et al., "Reversible binding of 5-and 8-methoxypsoralen to human serum proteins (albumin) and to epidermis in vitro," Brit. J. Derm. 101:669 (1979).
M.J. Metzelaar, Studies on the Expression of Activation-Markers on Human Platelets (Thesis 1991).
Meek, E. et al., "Bacterial Proliferation in Human Platelet Concentrates Stored in Plasma or Artificial Medium," P.F.1.90 (ISBT) (1988) Abstract.
Gasparro, et al., "Rapid and Sensitive Analysis of 8-Methoxypsoralen in Plasma," J. Invest. Dermatol. 90:234 (1988).
Knobler, Robert M. MD, et al., "Parenteral administration of 8-methoxypsoralen in photopheresis," J. American Acad. Derm. 28:581 (1993) .

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