Intravascular embolizing agent containing angiogenesis-inhibitin

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514492, 514762, 514763, 514770, 514787, 5147881, A61K 3100, A61K 31335

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active

052023524

ABSTRACT:
The present invention relates to an intravascular embolizing agent containing an angiogenesis-inhibiting substance and an intravascular embolizing substance. The agent strengthens the antitumor effect of an angiogenesis-inhibiting substance and serves to reduce the dose and undesirable side effects. And use of the agent in concert with an anti-neoplastic agent brings about further strong and long-lasting antitumor effects.

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Kato et al. "Sustained-Release Properties of Microencapsulated Mitomycin C with Ethylcellulose Infused in the Renal Artery of the Dog", Cancer, vol. 46, Jul. 1980, pp. 14-21.
Dakhil et al. "Improved Regional Selectivity of Hepatic Arterial B CNU with Degradable Microspheres" Cancer, vol. 50, Aug. 1982, pp. 631-635.
T. Kanamaru, Chemcial Abstracts, 114(12): 108951x.
Japanese Unexamined Patent Publication No. 97558/1987, Derwent Abstract attached.
Japanese unexamined Patent Publication No. 255231/1988, Derwent Abstract attached.
Japanese Unexamined Patent Publication No. 228910/1989, Derwent Abstract attached.

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