Intravaginal treatment of vaginal infections with buffered metro

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514944, 514967, A61K 31415

Patent

active

055367437

ABSTRACT:
A non-flowing composition and method for treatment of bacterial vaginosis are disclosed. An afflicted vagina is treated with a therapeutically effective but relatively low dose of metronidazole in a composition that includes a buffer system maintaining the composition at a pH value in the range of about 3.75 to about 4.25. The composition can also be used for prophylactic purposes.

REFERENCES:
patent: 4472376 (1984-09-01), Kamashita
patent: 4837378 (1989-06-01), Borgman
patent: 5266329 (1993-11-01), Riley, Jr.
Amsel R. et al. "Comparison of metronidazole, ampicillin, and amoxicillin for treatment of bacterial vaginosis (nonspecific vaginitis): possible explanation for the greater efficacy of metronidazole." In proceedings of the First U.S. Metronidazole Conference: pp. 225-242. Edited by Finegold S. M, George W. L., and Rolfe R. D. N.Y.: Biomedical Information Corporation (1982).
Balsdon M. J. et al. "Corynebacterium vaginale and vaginitis: a controlled trial of treatment." Lancet 1:501 (1980).
Bartlett J. G. et al. Bacterial flora of the vagina: quantitative study. Rev. Infect. Dis. (Suppl 1) 6:S67-S72 (1984).
Bistoletti P. et al. "Comparison of oral and vaginal metronidazole therapy for nonspecific bacterial vaginosis." Gynecol. Obstet. Invest. 21:114-149 (1986).
Brenner W. E. et al., "Metronidazole-containing vaginal sponges for treatment of bacterial vaginosis," Adv. Contracept. 2:363-369 (1986).
Centers For Disease Control. MMWR Supplement. "1985 STD treatment guidelines." Vol. 34 (4S), Oct. 18, 1985.
Charles D. et al. Antimicrobial treatment of infectious vaginopathies. The Female Patient 10:25-42 (1985).
Davis B. et al. Analysis of metronidazole penetration into vaginal fluid by reversed-phase high-performance liquid chromatography. Am. J. Obstet. Gynec. 149:802-803 (1984).
Edelman D. A. et al., "Treatment of bacterial vaginosis with intravaginal sponges contaning metronidazole," J. Reprod. Medicine 34(5):341-344 (1989).
Eschenbach D. A. et al. "A dose-duration study of metronidazole for the treatment of nonspecific vaginosis." Scand. J. Infect. Dis. (Suppl) 40:73-80 (1983).
Eschenbach D. A. et al. Diagnosis and clinical manifestations of bacterial vaginosis. Am. J. of Obstet. & Gynecol. 158:819-829 (1988).
Eschenbach D. A. et al. Prevalence of Hydrogen Peroxide-Producing Lactobacillus Species in Normal Women and Women with Bacterial Vaginosis. J. Clin. Microbiology 27(2):251-256 (1989).
Fouts A. C. et al. Trichomonas vaginalis: reevaluation of its clinical presentation and laboratory diagnosis. J. Infect. Diseases 141:137-143 (1980).
Hager W. D. et al. Metronidazole for vaginal trichomoniasis. Seven-day vs Single-dose regimens. J.A.M.A. 244:1219-1220 (1980).
Hagstrom B. et al. "Comparison of two different regimens of metronidazole in the treatment of nonspecific vaginitis." Scand. J. Infect. Dis. (Suppl) 40:95-96 (1983).
Hill, L. V. H. et al. Vaginitis: current microbiological & clinical concepts. Can. Med. Assoc. J. 134:321-331 (1986).
Hillier S. L. et al. "Efficacy of Metronidazole-Containing Sponges for the Treatment of Bacterial Vaginosis." ICAAC Abstract No. 1056, p. 281 (1989).
Larsen B. et al. Vaginal microbial flora: composition and influence of host physiology. Ann. Intern. Med. 96:926-930 (1982).
Malouf M. et al., Dube J-L. "Treatment of Hemophilus vaginalis vaginitis."Obstet. Gynecol. 57(6):711-714 (1981).
Mardh P. et al. In vitro interactions between Lactobacilli and other microorganisms occurring in the vaginal flora. Scand. J. Infect. Dis, (Suppl) 40:47-51 (1983).
McCue J. D. Evaluation and management of vaginitis. Arch Intern. Med. 149:565-568
Mead P. B. et al. "Establishing bacterial vaginosis." Contemp. OB/GYN 27:186-203 (Feb. 1986).
Mollgaard B. et al. Vehicle effect on topical drug delivery. II. Concurrent skin transport of drugs and vehicle components. Acta Pharm. Succ. 20:443-450 (1983).
Moorman C. N. et al. Impact of site release of vaginal pH buffer cream on introital colonization by gram-negative bacilli. J. Urology 147:1576-1578 (1992).
Nielsen P. G. Treatment of rosacea with 1% metronidazole cream. A double-blind study. Br. J. Dermatol. 108:327-332 (1983).
Nielsen P. G. A double-blind study of 1% metronidazole cream versus systemic oxytetracycline therapy for rosacea. Br. J. Dermatol. 190:63-65 (1983).
Peeters M. et al. Adhesion of Gardnerella vaginalis to vaginal epithelial cells: variables affecting adhesion and inhibition by metronidazole. Genitourin Med. 61:391-395 (1985).
Pheifer T. A. et al. "Nonspecific vaginitis: role of Haemophilus vaginalis and treatment with metronidazole." New Eng. J. Med. 298(26):1429-1434 (1978).
Purdon A. et al. An evaluation of single dose metronidazole treatment for Gardnerella vaginalis vaginitis. Obstet. Gynecol. 64:271 (1984).
Rein M. F. Vulvovaginitis and cervicitis, in Mandell G. L., Douglas R. G., Bennett T. E. (eds). Principles and Practice of Infectious Diseases, Edition 2, New York, John Wiley & Sons Inc., pp. 729-738 (1984).
Robie M. O. et al. Metronidazole use in obstetrics and gynecology: A review. Am. J. Obstet. Gynecol. 145:865-879 (1983).
Skavin A. et al. Vaginal Lactobacilli inhibiting growth of Gardnerella vaginalis, mobiluncus and other bacterial species cultured from vaginal content of women with bacterial vaginosis. Acta. Path. Microbial. Immunol. Scand., Section B, 94:399-403 (1986).
Staerfelt F. et al. A survey of genital infections in patients attending a clinic for sexually transmitted diseases. Scand. J. Infect. Dis. 40:53-57 (1983).
Swedburg J. et al. "Comparison of single dose versus one week course of metronidazole for symptomatic bacterial vaginosis." JAMA, 258:1046-1049 (1985).
Totten P. A. et al. Selective differential human blood filagen media for isolation of Gardnerella vaginalis. J. Clin. Microbiol. 15:141-147 (1982).
Compendium (Canada): Flagyl (Metronidazole) (1987).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Intravaginal treatment of vaginal infections with buffered metro does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Intravaginal treatment of vaginal infections with buffered metro, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intravaginal treatment of vaginal infections with buffered metro will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1784595

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.