Intravaginal drug delivery device

Details Intravaginal drug delivery device Intravaginal drug delivery device

1998-06-22

2000-03-21

Azpuru, Carlos A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

A61F 1302

Patent

active

060399686

ABSTRACT:
The invention provides an intravaginal drug delivery system having a first intravaginal part comprising at least one active agent in a polymer matrix, said first part being provided in association with a second part comprising a removable polymer membrane arranged to absorb excess active agent. Use of a polymer membrane in this way serves to substantially reduce the initial high burst of active from the intravaginal part following administration. It also reduces the levels of release of active during the first few weeks of use. Also provided is an intravaginal drug delivery device comprising at least one active agent dispersed in a polymer matrix, wherein the concentration of active agent at the outer surface of the device at the time of use is not substantially higher than the concentration of the active agent in the remainder of the device.

REFERENCES:
patent: 3545439 (1970-12-01), Duncan
patent: 4291014 (1981-09-01), Keith
patent: 4300561 (1981-11-01), Kaczmarzyk
patent: 5816248 (1998-10-01), Anderson
patent: 5855906 (1999-01-01), McClay

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