Surgery – Female reproductory tract shields – supports – or birth... – With contraceptive – spermacidal – or antifertility agent
Patent
1996-04-11
1997-12-09
Brown, Michael A.
Surgery
Female reproductory tract shields, supports, or birth...
With contraceptive, spermacidal, or antifertility agent
128832, A61F 606
Patent
active
056949472
DESCRIPTION:
BRIEF SUMMARY
The object of the present invention is an intravaginal delivery system, which comprises a flexible support means and a delivery means containing active agent and carried by the support means. Such delivery systems are used for administering various active and therapeutical agents which are absorbed through the vagina, for example for the administration of hormones in menopausal treatment.
A number of different constructional solutions of drug and contraceptive rings is known from literature. The simplest solutions are such wherein the delivery system is simply formed by a drug-containing polymer matrix in the form of a closed ring (U.S. Pat. No. 3,545,439). A variety of this is a closed ring which comprises a drug-free core surrounded by a drug matrix optionally containing a number of different drugs and in addition optionally an outermost polymer membrane (U.S. Pat. No. 3,920,805, U.S. Pat. No. 4,292,965). These solutions have the common disadvantage that the release of drug from these is difficult to regulate, which problem is enhanced in connection with a drug mixture.
A solution different from the above mentioned is disclosed for example in the U.S. Pat. No. 4,012,496, wherein the drug containing part of the ring is formed by one or several drug matrix strings embedded in a groove extending along the periphery of the ring and each containing only one drug. Depending on the particular drug and its release characteristics, the drug string can in some instances be very thin, which in turn gives rise to production-technical problems. An additional disadvantage in this construction is that the active agent has a tendency to diffuse from the drug string into the polymer body, which for its own part makes it difficult to control the release of the drug.
The simultaneous administration of several drugs by means of an intravaginal ring has been disclosed also in the U.S. Pat. No. 4,596,576. In this patent a solution is disclosed wherein active agent containing containers are mounted along the periphery of the ring, which containers are separated from each other with a plug or similar made from an inert material, which prevents the migration of drug from one container to the other, in order to ensure disturbance-free release of the drugs in the desired proportion. Metals, such as noble metals, glass, ceramics etc. have been suggested for use a inert materials. Also this solution is difficult from a production-technical viewpoint as different sized tube-shaped bodies of different materials are used, which have to be connected by gluing or in some other way.
The object of the present invention is to eliminate the disadvantages relating to the above mentioned known solutions, by providing a solution which is easy to manufacture and which guarantees the release of the drug or drugs in a controlled manner and in the correct proportions. The solution according to the invention is characterized in that the support means consists of a core member substantially in the form of an open ring, and the delivery means consists of at least one sleeve-like polymer body which encircles the core member in a beltwise manner along a part of the length of the core member.
The support means is naturally made of a material which is biologically compatible and remains unchanged also for prolonged periods of time in the conditions prevailing in the vagina.
According to the invention, the inner surface of the sleeve-like body is preferably in contact with a material, which substantially prevents the migration of active agent into the support means. Accordingly, part of the support means, such as its outer surface, at least adjacent the (sleeve-like body), or the support means in its entirity, can be made from a material which is substantially inert with respect to the active agent in the sleeve-like body. The term "substantially inert" means in this connection that the said active agent cannot, to any substantial degree, diffuse or in any other way migrate from the sleeve-like body into the support means. Suitable support or carrier mater
REFERENCES:
patent: 3920805 (1975-11-01), Roseman
patent: 3967618 (1976-07-01), Zaffaroni
patent: 3973560 (1976-08-01), Emmett
patent: 4012496 (1977-03-01), Schopflin et al.
patent: 4292965 (1981-10-01), Nash et al.
patent: 4596576 (1986-06-01), de Nijs
Lehtinen Matti
Talling Christine
Brown Michael A.
Leiras Oy
LandOfFree
Intravaginal delivery system does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Intravaginal delivery system, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intravaginal delivery system will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1600230