Intrapelvic perfusion therapy with cancer therapeutic agent...

Surgery – Blood drawn and replaced or treated and returned to body – Constituent removed from blood and remainder returned to body

Reexamination Certificate

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C604S006160, C604S096010

Reexamination Certificate

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07914478

ABSTRACT:
An intra pelvic cancer therapeutic agent perfusion apparatus and method for administering a cancer therapeutic agent to and recovering same from a cancer tissue site within the pelvis. The tip of a first sheath is percutaneously inserted into the femoral artery and the tip of a second sheath is inserted into the femoral vein. A first balloon catheter is inserted into the aorta through the femoral artery and a second balloon catheter is inserted into the vena cava through the femoral vein. The first balloon catheter is used to block the blood flow and the second balloon is inflated to form an intravenous closed region between the site of insertion in the vena cava and a lower limb side venous site. A body fluid containing a cancer therapeutic agent is administered to the intra arterial closed region through the first sheath and is removed therefrom through the second sheath.

REFERENCES:
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patent: 6699231 (2004-03-01), Sterman et al.
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Regional Chemotherapy for Cancer: Experiences with 116 Perfusions. Stehlin et al. Annals of Surgery, vol. 151, No. 4. pp. 605-619. Apr. 1960.
Isolated Pelvic Perfusion for Unresectable Cancer Using a Balloon Occlusion Technique. Turk et al. Arch Surg, vol. 128, pp. 533-539. May 1993.
Pharmacokinetic model and the clinical pharmacology of cis-platinum, fluorouracil and mitomycin-C in isolated pelvic perfusion. Wanebo et al. Cancer Chemother Pharmacol., 43: 427-434. 1999.
Preoperative Therapy for Advanced Pelvic Malignancy by Isolated Pelvic Perfusion with the Bolloon-Occlusion Technique. Wanebo et al. Annals of Surgical Oncology, 3(3):295-303, 1996.
Chemotherapy of Cancer: Regional Perfusion Utilizing an Extracorporeal Circuit. Creech, Jr. et al. Annals of Surgery, vol. 148, No. 4. pp. 616-632. Oct. 1958.

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