Intraorgan injection of biologically active compounds contained

Details Intraorgan injection of biologically active compounds contained Intraorgan injection of biologically active compounds contained

1989-05-01

1991-05-21

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424423, 424426, A61F 200

Patent

active

050173782

ABSTRACT:
A method for increasing fertility in males with impairment of testosterone synthesis, comprising the step of injecting slow-release microcapsules or microspheres containing testosterone directly into the testes. The testosterone-laden microcapsules or microspheres act as temporary Leydig cells and release testosterone directly into the testicular parenchyma and maintain high intratesticular concentrations of testosterone needed for spermatogenesis.

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Lewis et al., "Overview of Controlled Release Systems of Male Contraception", Male Contraception: Advances and Future Prospects, Harper & Rowe, pp. 336-346 (U.S.A. 1986).
Asch et al., "Preliminary Results on the Effects of Testosterone Microcapsules", Male Contraception: Advances and Future Prospects, Harper & Rowe, pp. 347-360 (U.S.A. 1986).
Beck et al., "New Long-Acting Injectable Microcapsule Contraceptive System", J. Obstet. Gyn., 135:419-426 (U.S.A. 1979).
Beck et al., "Clinical Evaluation of Injectable Biodegradable Contraceptive System", Am. J. Obstet, Gynec., 140:799-806 (U.S.A. 1981).
Beck et al., "Clinical Evaluation of an Improved Injectable Microcapsule Contraceptive System", Am. J. Obstet. Gynec., 147:815-821 (U.S.A. 1983).
Rivera et al., "Norethisterone Microspheres 6-Month System: Clinical Results", Long-Acting Contraceptive Delivery Systems, Harper & Rowe (U.S.A. 1984).

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