Surgery – Diagnostic testing – Measuring or detecting nonradioactive constituent of body...
Reexamination Certificate
2000-07-20
2002-08-06
Winakur, Eric F. (Department: 3736)
Surgery
Diagnostic testing
Measuring or detecting nonradioactive constituent of body...
C600S322000, C600S344000
Reexamination Certificate
active
06430422
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a jig for non-invasively measuring a physical quantity of a vital tissue by bringing a projecting/photoreceiving forward-end-surface into contact with an organism. This jig is used, for example, for irradiating a human body with light of a near-infrared region and measuring a physical quantity in the human body such as a glucose concentration in blood or oxygen saturation of blood by an output light from the human body through the light.
2. Description of the Prior Art
In the field of clinical testing, a non-invasive measuring method of irradiating an organism with light and measuring oxygen saturation in blood or a blood-sugar level from output light is attempted. The organism is a scatterer having an internal structure complicatedly varying with places, and hence an optical path length of light must be made constant in the organism, in order to measure a concentration of blood-sugar level and the like.
When bringing a measuring probe into contact with a vital tissue for applying light and measuring output light, influence is exerted by position reproducibility, the degree of contact, the surface temperature of a human body, the thickness of a corneum layer, a moisture content, and the like. In order to avoid such influence, intraoral measurement with a mouthpiece is proposed (refer to “Medical Electronics and Bioengineering”, Vol. 35, special edition (April 1997), p. 512).
In this proposal, pulse waves, pulses and oxygen saturation are listed as objects measured with light. In measurement of these objects, however, absolute value measurement does not have to be made and hence necessity for noting the degree of adhesion between the mouthpiece and the oral cavity and the degree of contact between an optical light guide component such as an optical fiber member and the oral cavity is low and not sufficiently taken into consideration. Therefore, when measuring a physical quantity of such as a blood-sugar level requiring absolute value measurement, reproducibility is deteriorated. When a projecting/photoreceiving forward-end-surface projecting measuring light and receiving scattered light from an organism is inferiorly in contact with an intraoral surface, it comes to also receive light reflected by the intraoral surface leading to deterioration of an S-N (signal-to-noise) ratio. Contrary to this, when the contact between the projecting/photoreceiving forward-end-surface and the organism is too strong, congestion takes place.
The temperature of the mouthpiece coming into contact with the intraoral surface is also important. If a vital tissue is influenced by the temperature of the mouthpiece, the obtained absorption-spectrum disadvantageously changes.
SUMMARY OF THE INVENTION
An objective of the present invention is to provide a jig for intraorally measuring a physical quantity of a vital tissue with excellent reproducibility.
The present invention is directed to an intraoral jig for optical measurement comprising a jig body having a shape engaging with upper and lower backsides of teeth of a measured person and coming into contact with an oral cavity part, a projecting/photoreceiving part embedded in the jig body so that a projecting/photoreceiving forward-end-surface is flush with a portion coming into contact with the oral cavity part for projecting measuring light to the oral cavity part and receiving an output light from the oral cavity part through the measuring light on the forward-end-surface, a temperature control mechanism keeping a temperature of the jig body constant and a pressure sensor embedded in the jig body for detecting a pressure for holding the jig body between the upper and lower teeth of the measured person.
The output light from the oral cavity part and received by the projecting/photoreceiving part includes all light output from the oral cavity part such as transmitted light, scattered light and reflected light after projection of the light to a human body.
This jig body has the shape engaging with the upper and lower backsides of teeth of the measured person and coming into contact with the oral cavity part, and the projecting/photoreceiving part is embedded in the jig body so that the forward-end-surface thereof is flush with the portion of the jig body coming into contact with the oral cavity part, whereby contact between the forward-end-surface of the projecting/photoreceiving part and the internal surface of the oral cavity as well as position reproducibility are improved. Furthermore, influence by the temperature can be eliminated by keeping the temperature of the jig body constant with the temperature control mechanism, and influence by the pressure can also be eliminated by holding the jig between the upper and lower teeth of the measured person so that the pressure detected by the pressure sensor is constant.
The projecting/photoreceiving part includes a projecting part and a photoreceiving part. These parts can be arranged to be close to or separate from each other.
The projecting part can be a light-guide-path such as an optical fiber bundle guiding the measuring light from a light source. In this case, the degree of freedom in light source selection is increased, wavelength selection is easy, and it is also easy to obtain high luminous energy. It is also possible to arrange a spectroscope separating the light from the light source into its spectral components between the light source and the light-guide-path. Alternatively, the projecting part can be provided with a light emitting device such as an LED (light emitting diode) or an LD (laser diode) embedded therein.
The photoreceiving part can be a light wave path such as an optical fiber bundle guiding the received output light to a detector. In this case, the degree of freedom in detector selection is increased. It is also possible to arrange a spectroscope separating the output light into its spectral components between the light-guide-path and the detector. Alternatively, the photoreceiving part can be provided with a photoreceiving element such as a photodiode or a phototransistor embedded therein.
Light from near-infrared or infrared region is preferable as light for measuring a physical quantity of a vital tissue. The light source being used, generating light included in such a wavelength region, may include a continuous spectrum or discontinuous bright line spectra in this wavelength region. An LED or an LD for near-infrared or infrared emission can be employed as such a light source, in addition to a tungsten-halogen lamp.
The detector or the photoreceiving element is sensitive to a near-infrared or infrared region, and a Ge photodiode, an InGaAs photodiode, a PbS photoconductive element, a PbSe photoconductive element, an InAs photovoltaic element or a pyroelectric element can be employed as such an infrared detector.
If the temperature is around the body temperature of a human body when keeping the temperature of the jig body by the temperature control mechanism constant, influence by the temperature is preferably minimized. The foregoing and other objects, features, aspects and advantages of the present invention will become more apparent from the following detailed description of the present invention when taken in conjunction with the accompanying drawing.
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Kremer Matthew
Kurabo Industries Ltd.
Rader & Fishman & Grauer, PLLC
Winakur Eric F.
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