Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-10-11
1996-04-02
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 31495, A61K 3150
Patent
active
055040861
ABSTRACT:
A method of therapeutically administering certain BZ.sub.1 specific trifluorobenzodiazepines in order to maximize the BZ.sub.1 effects and minimize the BZ.sub.2 effects on the human central nervous system in order to maximize the anti-anxiety, anticonvulsant and hypnotic effects and minimize the ataxic and incoordination effects of the drug. Also, a method of sublingual administration of trifluorobenzodiazepines and certain other compounds, such as propoxyphene and nefazodone, in order to decrease unwanted metabolites.
REFERENCES:
patent: 4613600 (1986-09-01), Gummans
Zohar et al., "Serotonergic Responsivity in Obsessive-Compulsive Disorder", Arch Gen Psychiatry, vol. 44, pp. 946-951 (Nov. 1987).
Kahn et al., "Behavioral Indications for Serotonin Receptor Hypersensitivity in Panic Disorder", Psychiatry Research, vol. 25, pp. 101-104 (1988).
Hollander et al., "Serotonergic and Noradrenergic Sensitivity in Obsessive-Compulsive Disorder: Behavioral Findings", American Journal of Psychiatry, vol. 145:8, pp. 1015-1017 (Aug. 1988).
Walsh et al., "Neuroendocrine and Temperature Effects of Nefazodone in Healthy Volunteers", Biological Psychiatry, vol. 33, pp. 115-119 (1993).
Shukla et al., "Pharmacokinetics, Absolute Bioavailability, and Disposition of .sup.14 C! Nefazodone in the Dog", Drug Metabolism and Disposition, vol. 21, No. 3, pp. 502-507 (1993).
Shukla et al., "Pharmacokinetics of Nefazodone Following Multiple Escalating Oral Doses in the Dog", European Journal of Drug Metabolism and Pharamcokinetics, vol. 17, No. 4, pp. 309-318 (1992).
Ellinwood, Jr. Everett H.
Gupta Samir K.
Criares Theodore J.
Jenkins Richard E.
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