Intraoral dosing method of administering medicaments

Details Intraoral dosing method of administering medicaments Intraoral dosing method of administering medicaments

1996-03-27

1998-04-14

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

A61K 31495

Patent

active

057391360

ABSTRACT:
A method of therapeutically administering certain medicaments in order to maximize the desired effects and minimize the unwanted metabolite effects on the human body, including the central nervous system, in order to maximize therapeutic effects, such as anti-anxiety, anticonvulsant and hypnotic effects, and minimize unwanted side effects, such as ataxic and incoordination effects, of the drug. Also, a method of sublingual or buccal administration of certain medicaments in order to decrease metabolism of the medicaments to unwanted metabolites.

REFERENCES:
Posner et al., European Journal of Clinical Pharmacology, "The Disposition of Bupropion and Its Metabolites in Healthy Male Volunteers After Single and Multiple Doses", vol. 29, pp. 97-103 (1985).
Workman et al., American Journal of Psychiatry, "Trazodone Induction of Migraine Headache Through mCPP", vol. 149, p. 5 (May, 1992).
DeVane et al., Fundamentals of Monitoring Psychoactive Drug Therapy, pp. 44-46 (1990).
Golden et al., Archives of General Psychiatry, "Bupropion in Depression", vol. 45, pp. 145-149 (Feb., 1988).

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