Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1998-09-03
1999-11-30
McDermott, Corrine
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
128859, 424435, 433 37, 433 80, A61J 700
Patent
active
059934131
DESCRIPTION:
BRIEF SUMMARY
The object of the present invention is an intraoral administration device comprising an elongated, substantially plate-like curved oral screen designed to conform to the teeth and intended to be positioned in the space between the teeth and the lips. The object of the present invention is also an administration system, which comprises the administration device according to the invention in combination with an active agent.
By means of the administration system according to the invention it is possible to provide a sustained local therapeutic effect in the region of the mouth and throat which is adapted to take into account the eruption order of the teeth and the location of the salivary glands, while simultaneously satisfying the physiological sucking need and craving for sweetness of small children, using small dosage levels tolerated by children and without causing malocclusions, especially when the sucking need of the child continues too long from the orthodontic point of view.
Various dispensing pacifiers are known (for example U.S. Pat. No. 4,078,566, GB-patent application 2 181 957A; EP Pat. No. 0 494 904, FI-patent application FI-A 921411, U.S. Pat. No. 5,395,392; and the commercially available CANNON babysafe Minifeeder). Suhonen (1992) has presented the theoretical background for the use of a pacifier like administration device which slowly releases fluorides, xylitol, monoclonal caries antibodies or lactoperoxidase enzyme components into the mouth, in a prophylactic method for the prevention of dental caries. The operability of a dispensing pacifier for releasing sodium fluoride, xylitol and sorbitol from a tablet has been established in vitro, and the administration from a pacifier of passive vaccines against microbes causing oral diseases has been suggested (Suhonen at al, 1994). A pacifier prototype for dispensing sodium fluoride, xylitol and sorbitol has in our field trial with children of the age of 16 months proved to be a functioning weans with potential for development for the treatment of diseases of the mouth and throat of children in the sucking-age. In our follow-up study it also became evident that in the group of children that had accepted the test pacifier, there appeared significantly less often infection of the middle ear (otitis media, 48% versus 70%) than in the comparison group. Recently it has been shown that xylitol also inhibits the growth of Streptococcus pneumoniae (pneumococcus) (kontiokari et al 1995). According to one report (October 1996) the use of a xylitol bubble gum several times a day has reduced infection in the middle ear in kindergarten children in Oulu. The mouth cavity can thus be an area of primary defense in the battle against bacteria aiming for the middle ear.
In the continuous follow-up of our study cohort, it has been established that malocclusions in children using a pacifier become significantly more common when the use of the pacifier continues beyond the age of two. For this reason, taking into account the individual dentoalveolar jaw development, the pacifier should be given up at the stage of eruption of the deciduous molars which, on an average, coincides with that age, at which stage the sucking-need of a child optimally should already have changed into a chewing-need (Laitinen 1995). To prevent malocclusions Varrela and Alanen (1995) have presented an extensive pacifier study with an aim at finding a pacifier model which broadens the dental arch of the upper jaw. Prolonged pacifier sucking has also been alleged to cause middle ear infection (Niemela 1984). On the other hand, if the pacifier is taken away from a child too early, he easily becomes a thumb-sucker which, from the point of view of bite development, is an even worse habit than sucking a pacifier. Also deciduous dentition destroyed by early caries attack cause displacements and malocclusion of the permanent teeth.
According to the invention, an administration device of the oral screen type has now been developed, by means of which an active agent can be slowly released into the mouth
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J. Suhonen et al., "Release of Preventive Agents from Pacifiers in Vitro. An Introduction to a Novel Preventive Measure," Schweiz. Monatsschr. Zahnmed., 1994, 104;945-51.
Aaltonen Antti Sakari
Suhonen Jouko
McDermott Corrine
Thanh Loan H.
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