Intraocular pressure lowering composition for topical use

Details Intraocular pressure lowering composition for topical use Intraocular pressure lowering composition for topical use

1987-01-14

1989-05-02

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514913, A61K 31135

Patent

active

048268798

ABSTRACT:
An ocular antihypertensive composition for topical use which contains an effective amount of a compound represented by the formula ##STR1## or a salt thereof having, in low concentrations, intraocular pressure lowering activity in mammals, low toxicity and no influence on the pupil size and, therefore, is useful as a therapeutic agent for glaucoma, for instance.
Furthermore, since the compound is effective in low concentrations, the possibility of tolerance development is considered to be scarce.

REFERENCES:
patent: 4010202 (1977-03-01), Sugihara et al.
patent: 4035512 (1977-07-01), Sugihara et al.
Chem. Abst. 85: 20935s (1976)-Sugihara et al.
Chem. Abst. 89: 75331(e) (1978)-Sugihara et al.

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