Intraocular lens containing releasable medication

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

Reexamination Certificate

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Reexamination Certificate

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07939097

ABSTRACT:
An intraocular implant adapted to come in contact with the aqueous humor comprises a hydrophilic polymer having a predetermined water content for implantation in an eye, an effective quantity of a medicated product for treatment of the eye being dispersed in the mass of the hydrophilic polymer of the implant, the association of the hydrophilic polymer and the dispersed medicated product being adapted to release the product progressively into the aqueous humor.

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ASHP Guidelines for ophthalmic products, 2 pages (Approved Apr. 1993).
T. Heyrman et al., “Drug Uptake and Release by a Hydrogel Intraocular Lens and the Human Crystalline Lens,” J. Cataract Refractive Surgery, vol. 15, No. 2, 1989, pp. 169-175.
O. Nishi et al., “Effect of Indomethacin-Coated Posterior Chamber Intraocular Lenses On Postoperative Inflammation and Posterior Capsule Opacification,” Journal of Cataract & Reflective Surgery, vol. 21, No. 5, 1995, pp. 574-578.
J. Chapman et al., “Drug Interaction with Intraocular Lenses of Different Materials,” Journal of Cataract & Reflective Surgery, vol. 18, No. 5, 1992, pp. 456-459.
S. Meski et al., “Use of Methyl Polymethacrylate (PMMA) As a Drug Support,” Proc. 1stWorld Meeting APGI/APV, vol. 9, No. 11, 1995, pp. 323-324.

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