Intranasal vaccination of horses with inactivated microorganisms

Details Intranasal vaccination of horses with inactivated microorganisms Intranasal vaccination of horses with inactivated microorganisms

1987-08-27

1990-07-31

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Lymphokine

424 92, A61K 3909, A61K 3912

Patent

active

049449427

ABSTRACT:
Horses can be immunized by the intranasal administration of antigenic material which provokes the proliferation of antibodies which reduce or neutralize the virulence of invasive microorganisms. These antigenic materials may be inactivated whole organisms, extracts from such organisms, or recombinant DNA or synthetic peptide antigens. This antigenic material can be combined with adjuvants and transdermal carriers or it can just be carried in sterile water. The intranasal vaccination may be part of a total regimen that includes other routes of administration such as intramuscular injection.

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patent: 4582798 (1986-04-01), Brown et al.
Polly et al., Journal of Infectious Diseases, vol. 131, No. 3, pp. 217-224, Human Strept Vaccine Aerosol Spray, Protective Studies with a Group A Streptococcal M. Protein Vaccine, Mar. 1975.
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