Intranasal formulations for promoting sleep and method of using

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514923, A61K 908, A61K 31435

Patent

active

058744509

ABSTRACT:
Intranasal dosage units for promoting sleep in a mammal are disclosed. The dosage units are in the form of an aqueous buffered solution having a pH greater than 7.0, a sleep-promoting amount of Doxylamine, and an effective amount of an anionic surfactant. The anionic surfactant amount is an amount effective to provide a peak plasma concentration of Doxylamine to be reached within 30 minutes of administering the dosage unit to the nasal mucosa of a mammal. The dosage units are particularly suitable for administration to humans.

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Pharmaceutical Research--PDD 7485--"Development of a Doxylamine Succinate Nasal Solution and its Comparison With Oral Doxylamine Succinate Product", Sep. 1995 (Supplement) vol. 12, No. 9.

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