Intramyocardial injection of autologous bone marrow

Details Intramyocardial injection of autologous bone marrow Intramyocardial injection of autologous bone marrow

2006-08-29

2006-08-29

Vogel, Nancy (Department: 1636)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

C435S384000, C435S372000

Reexamination Certificate

active

07097832

ABSTRACT:
A method of treating cardiac or myocardial conditions comprises the administration of an effective amount of autologous bone marrow. The bone marrow may optionally be stimulated and/or administered in combination with a pharmaceutical drug, protein, gene or other factor or therapy that may enhance bone marrow production of angiogenic growth factors and/or promote endothelial cell proliferation or migration or blood vessel formation.

REFERENCES:
patent: 5610056 (1997-03-01), Nakahata
patent: 5817773 (1998-10-01), Wilson et al.
patent: 5980893 (1999-11-01), Avraham et al.
patent: 5997860 (1999-12-01), Bauer et al.
patent: 6013780 (2000-01-01), Neufeld et al.
patent: 6676937 (2004-01-01), Isner et al.
patent: 2005/0031600 (2005-02-01), Mickle et al.
patent: WO 91/04274 (1991-04-01), None
patent: WO 99/00486 (1999-01-01), None
patent: WO00/57922 (2000-10-01), None
Perin et al. Circulation, 2003; 107 :2294-2302.
Stamm et al. Lancet, 2003 ; 361 :45-6.
Tao and Ma. Pathology, 2003; 35:6-13.
Tomita et al. Circulation, 1999 ; 100(Supp II) :II-247-II-256.
Chiu, RC. Expert. Opin. Biol. Ther. 2003; 3(2):215-25.
Liechty et al. Nat. Med. 2000; 6(11): 1282-1286.
Aoki et al. Blood. Jun. 1999; 93:4034-43.
Mack et al. J. Thor. Cardio. Surg. 1998; 115:168-77.
Cashman et al. Blood, 1998; 92: 2338-44.
Fuchs et al. J. Am. Coll. Cardiol. 2001; 37: 1726-32.
S. Fuchs, et al., “Transendocardial Delivery of Autologous Bone Marrow Enhances Collateral Perfusion and Regional Function in Pigs with Chronic Experimental Myocardial Ischemia,”Journal of American College of Cardiology,2001, vol. 37, No. 6, pp. 1726-1732.
C. Kalka, et al., “Angiogenesis and Vasculogenesis,”Herz,2000, vol. 25, No. 6, pp. 611-622.
B.E. Strauer, M.D., et al., “Stem Cell Therapy in Perspective,”Circulation,2003, vol. 107, pp. 929-934.
Blume and Thomas, “A Review of Autologous Hematopoietic Cell Transplantation,”Biology of Blood and Marrow Transplantation,vol. 6, 2000, pp. 1-12.
Brugger, Wolfram et al., “Ex Vivo Manipulation of Hematopoietic Stem and Progenitor Cells,”Seminars in Hematology,vol. 37, No. 1, Supplement 2, Jan. 2000, pp. 42-49.
Dini, G. et al., “Peripheral Blood Stem Cell Collection from G-CSF-Stimulated Unrelated Donors for Second Transplant,”Bone Marrow Transplantation,vol. 22, Supplement 5, 1998, pp. S41-S45.
Fielding and Goldstone, “Autologous Bone Marrow Transplantation,”Current Opinion in Hematology,vol. 1, 1994, pp. 412-417.
Kanj, Souha S. et al., “Myocardial Ischemia Associated With High-Dose Carmustine Infusion,”Cancer,vol. 68, Nov. 1, 1991, pp. 1910-1912.
Noishiki, Yasuharu et al., “Angiogenic Growth Factor Release System for In Vivo Tissue Engineering: A Trial of Bone Marrow Transplantation into Ischemic Myocardium,”J. Artif. Organs,vol. 2, 1999, pp. 85-91.
Simnett, S.J. et al., “Autologous Stem Cell Transplantation for Malignancy: A Systematic Review of the Literature,”Clin. Lab. Haem.,vol. 22, 2000, pp. 61-72.
Vaughan, William P., et al., “Roundtable Discussion: Incorporating Bone Marow Transplantation Into NCCN Guidelines,”Onocology,vol. 12, No. 11A, NCCN Proceedings, Nov. 1998, pp. 390-392.
Dubrey et al., “Improvement of Echocardiographic and Electrocardiographic features in AL Cardiac Amyloidosis with Intensive Melphalan and Autologous Stem Cell Rescue”Boston University School of Medicine,XP-00107 135.
Isner and Asahara, “Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization”The Journal of Clinical Investigation103 (9):1231-1236 (1999).
Karen K. Fields, “Autologous Bone Marrow Transplantation and Melanoma: A Focused Review of the Literature”Annals of Plastic Surgery28 (1):70-73 (1992), XP-001069809.
Noishiki et al., “Autocrine angiogenic vascular prosthesis with bone marrow transplantation”Nature Medicine,2 (1):90-93 (1996).
Tomita et al., “Autotransplanted Mesenchymal Stem Cells Improve Functions After A Myocardial Infarction,”Circulation98 (17):1200 Abstract 1037.
Yamauchi et al., “New agents for the treatment of infracted myocardium”The FASEB Journal10.1096/fj.99-0565fje (2000).
S. Fuchs, et al., “Transendocardial Delivery of Autologous Bone Marrow Enhances Collateral Perfusion and Regional Function in Pigs with Chronic Experimental Myocardial Ischemia,”Journal of American College of Cardiology,2001, vol. 37, No. 6, pp. 1726-1732.
C. Kalka, et al., “Angiogenesis and Vasculogenesis,”Herz,2000, vol. 25, No. 6, pp. 611-622.
B.E. Strauer, M.D., et al., “Stem Cell Therapy in Perspective,”Circulation,2003, vol. 107, pp. 929-934.
Anderson, “Human gene therapy”,Nature,392(6679 Supp.):25-30 (Apr. 1998).
Bickenbach et al., “Selection and Extended Growth of Murine Epidermal Stem Cells in Culture”,Exp. Cell Res.,244(1):184-195 (Oct. 1998).
Blanquaert et al., “RGTA modulates the healing pattern of a defect in a monolayer of osteoblastic cells by acting on both proliferation and migration”,J. Biomed. Mater. Res.,64A(3):525-532 (Mar. 2003).
Asahara, T. et al., “Gene therapy of endothelial progenitor cell for vascular development in severe ischemic disease”,Circulation,vol. 100, (1999) pp. 1-481, Abstract XP009051610.
Isner, Jeffrey M., “Myocardial gene Theapy”,Nature(London) vol. 415, No. 6868, (2002) pp. 234-239.
Chiu, “Adult stem cell therapy for heart failure”,Expert Opin Biol Ther.,Apr. 2003, 3(2):215-25.
Desgranges et al., “Beneficial use of fibroblast growth factor 2 and RGTA, a new family of heparan mimics, for endothelialization of PET prostheses”,J Biomed Mater Res.,2001, 58(1):1-9.
Dowell et al., “Myocyte and myogenic stem cell transplantation in the heart”,Cardiovasc Res.,May 2003, 58(2):336-50.
Folkman, “Therapeutic angiogenesis in ischemic limbs”,Circulation,Mar. 1998, 97(12):1108-10.
Iwaguro et al., “Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration”,Circulation,,Feb. 2002, 105(6):732-8.

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