Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Diagnostic or test agent produces in vivo fluorescence
Patent
1998-05-14
2000-07-04
Clardy, S. Mark
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Diagnostic or test agent produces in vivo fluorescence
424 91, 424 9, 424 111, 424 165, 600 9, A61K 4900, G01N 3100, G01N 3348
Patent
active
060834862
ABSTRACT:
An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.
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Bogdanov Alexei
Josephson Lee
Mahmood Umar
Tung Ching-Hsuan
Weissleder Ralph
Clardy S. Mark
Jones Dameron
The General Hospital Corporation
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