Intramolecularly crosslinked hemoglobin

Details Intramolecularly crosslinked hemoglobin Intramolecularly crosslinked hemoglobin

1983-10-28

1984-09-25

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, 424101, 424177, 544244, C07C10352, C07G 700, A61K 3514

Patent

active

044734964

ABSTRACT:
This invention relates to molecular modification of hemoglobin by utilizan of a class of .alpha., .omega.-dialdelhydes having a chain length of 5 to 7 members and substituted with at least one negatively charged group such as a phosphate moiety. A subject .alpha., .omega.-dialdehyde can be synthesized by sodium periodate oxidation of a phosphorylated ribose such as adenosine-5'-triphosphate or 5-phosphoribosyl-1-pyrophosphate. The compounds of this invention can be advantageously used for intramolecularly crosslinking hemoglobin for resuscitative purposes.

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