Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-01-06
1996-11-12
Naff, David M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
435101, 536 186, A01N 4304, A61K 31715, C07G 300, C12P 1904
Patent
active
055740235
ABSTRACT:
The invention stabilizes single helix conformation (1.fwdarw.3)-.beta.-D-glucans by intramolecular crosslinking and provides (1.fwdarw.3)-.beta.-D-glucans showing stable biological activities. Thus, intramolecularly crosslinked (1.fwdarw.3)-.beta.-D-glucans having a stable single helix conformation are produced by introducing a functional group into hydroxyl groups of (1.fwdarw.3)-.beta.-D-glucans, then causing the thus-obtained functional glucans to take a single helix conformation, and subjecting these, either as such or after binding them to a receptor therefor, to intramolecular crosslinking between the functional groups introduced, if necessary followed by releasing the receptor therefrom.
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Aketagawa Jun
Shibata Yuko
Tanaka Shigenori
Naff David M.
Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation)
Ware Deborah K.
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