Intramolecular arbuzov process for the preparation of intermedia

Details Intramolecular arbuzov process for the preparation of intermedia Intramolecular arbuzov process for the preparation of intermedia

1992-12-07

1993-12-28

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

560 56, 560 60, 560 61, 562466, 562470, 562471, 558179, 558182, 548110, 548119, 548413, 548414, 549 4, 549 6, 549214, 549218, 549226, C07F 708, C07F 718

Patent

active

052741559

ABSTRACT:
A process for the preparation of compounds of formula ##STR1## and pharmaceutically acceptable salts thereof; wherein X is --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C-- or --CH.sub.2 O-- (where O is linked to Z); Z is a hydrophobic anchor R.sub.1 is hydrogen, alkyl, cycloalkyl or aryl; comprising the steps of:

REFERENCES:
V. Sawitsch, "Ueber einige vom Aethylen sich ableitende Vervindungen", Justus Liebig's Annalen der Chemie, 119, (1861), pp. 182-185.
G. Eglinton et al., "The Coupling of Acetylenic Compounds", Advan. Org. Chem, 4, 91963), pp. 225-328.

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