Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Arterial prosthesis – Drug delivery
Reexamination Certificate
2006-11-14
2006-11-14
Stewart, Alvin J. (Department: 3738)
Prosthesis (i.e., artificial body members), parts thereof, or ai
Arterial prosthesis
Drug delivery
Reexamination Certificate
active
07135039
ABSTRACT:
The radially expandable prosthesis for implantation in a lumen comprises a tubular wall produced from sheet metal and showing cuts enabling the prosthesis to expand. By using water guided laser cutting technology to make these cuts and/or specific electrochemical polishing technology a more biocompatible prosthesis is obtained, causing less thrombogenicity and less foreign body reaction. By covering an intraluminal prosthesis with a titaniumnitride coating the biocompatibility of the prosthesis is improved. By applying perforating or non-perforating holes (4) and filling these holes with a therapeutic agent, the intraluminal prosthesis can be used to locally administer medicines, genes and or other substances to prevent in this way thrombotic occlusions and/or neointimal hyperplasia and prosthesis narrowing. Using this specific perforated prosthesis design the total drug capacity can be increased and also the drug release time prolongs significantly.
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Waterjet-guided lasers cut precisely; WWW.INDUSTRIAL-LASERS.COM/ARCHIVE/199/11/1199FEA6.HTML; Nov. 1, 1999; XP002176036.
News-Apr. 1, 1997; WWW.INDUSTRIAL-LASERS.COM/ARCHIVE/1997/04/0497NEWS.HTML; XP002176037.
De Scheerder Ivan
Sohier Jürgen
van der Leden Natasja
Van Humbeeck Jan
Boston Scientific Scimed Inc.
Vidas Arrett & Steinkraus
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