Intragastric stent for duodenum bypass

Details Intragastric stent for duodenum bypass Intragastric stent for duodenum bypass

2002-01-25

2004-05-25

Willse, David H. (Department: 3738)

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

Hollow or tubular part or organ

C623S023650

Reexamination Certificate

active

06740121

ABSTRACT:

FIELD OF THE INVENTION
The present invention relates to an impervious, resilient, flexible, biocompatible stent that can be secured in the duodenum adjacent to the pylorus to effect weight loss over a controlled period.
BACKGROUND OF THE INVENTION
The incidence of obesity and its associated health-related problems have reached epidemic proportions in the United States. See, for example, P. C. Mun et al., “Current Status of Medical and Surgical Therapy for Obesity”
Gastroenterology
120:669-681 (2001). Recent investigations suggest that the causes of obesity involve a complex interplay of genetic, environmental, psycho-behavioral, endocrine, metabolic, cultural, and socio-economic factors. Severe obesity is frequently associated with significant comorbid medical conditions, including coronary artery disease, hypertension, type II diabetes mellitus, gallstones, nonalcoholic steatohepatitis, pulmonary hypertension, and sleep apnea.
Estimates of the incidence of morbid obesity are approximately 2% of the U.S. population and 0.5% worldwide. Current treatments range from diet, exercise, behavioral modification, and pharmacotherapy to various types of surgery, with varying risks and efficacy. In general, nonsurgical modalities, although less invasive, achieve only relatively short-term and limited weight loss in most patients. Surgical treatments include gastroplasty to restrict the capacity of the stomach to hold large amounts of food, such as by stapling or “gastric banding.” Other surgical procedures include gastric bypass and gastric “balloons” which, when deflated, may be inserted into the stomach and then are distended by filling with saline solution.
The need exists for cost effective, less invasive interventions for the treatment of morbid obesity.
SUMMARY OF THE INVENTION
The present invention provides a novel system for treatment of morbid obesity by use of a bioabsorbable stent fitted snugly in the duodenum adjacent to the pylorus and impervious to digestive juices to limit the uptake of food passing through the stent. The stent is thin-walled, elastic, and flexible so as not to interfere with normal shifting of the duodenum nor with the passage of food therethrough. The stent can be formed of bioabsorbable material such that after a predetermined period the stent degrades and passes out of the body without the necessity for additional surgical intervention.
In the preferred embodiment, the stent includes a weave of bioabsorbable filaments and a covering or coating of impervious material or membrane. Alternatively, the weave can be integrated within the membrane. The filaments preferably have memory characteristics tending to exert moderate pressure against the interior wall of the duodenum, and the stent can possess regional variable strength, structure and bioabsorption pharmacokinetics. The stent can be secured in place by sutures at its proximate and distal ends.


REFERENCES:
patent: 4315509 (1982-02-01), Smit
patent: 4648383 (1987-03-01), Angelchik
patent: 5306300 (1994-04-01), Berry
patent: 2002/0161341 (2002-10-01), Stinson et al.
patent: 2003/0040804 (2003-02-01), Stack et al.
Benjamin, S.B., et al., “Double-Blind Controlled Trial of the Garren-Edwards Gastric Bubble: An Adjunctive Treatment for Exogenous Obesity,”Gastroenterology 95(3):581-588, Sep. 1988.
Coelho, J.C.U., and Campos, A.C.L., “Surgical Treatment of Morbid Obesity,”Current Opinion in Clinical Nutrition and Metabolic Care 4(3):201-206, May 2001.
Hubert, H.B., et al., “Obesity as an Independent Risk Factor for Cardiovascular Disease: A 26-year Follow-up of Participants in the Framingham Heart Study,”Circulation 67(5):968-977, May 1983.
Kral, J.G., “Gastric Balloons: A Plea for Sanity in the Midst of Balloonacy,”Gastroenterology 95(1):213-215, Jul. 1988.
Kral, J.G., “Overview of Surgical Techniques for Treating Obesity,”American Journal of Clinical Nutrition 55(2):552S-555S, 1992.
Macgregor, A.M.C., and Rand, C.S.W., “Gastric Surgery in Morbid Obesity,”Archives of Surgery 128(10):1153-1157, Oct. 1993.
MacLean, L.D., et al., “Results of the Surgical Treatment of Obesity,”The American Journal of Surgery 165:155-162, Jan. 1993.
Mathus-Vliegen, E.M.H., et al., “Intragastric Balloon in the Treatment of Super-morbid Obesity,”Gastroenterology 99(2):362-369, Aug. 1990.
Meshkinpour, H., et al., “Effect of Gastric Bubble as a Weight Reduction Device: A Controlled, Crossover Study,”Gastroenterology 95(3):589-592, Sep. 1988.
Mun, E.C., et al., “Current Status of Medical and Surgical Therapy for Obesity,”Gastroenterology 120(3):669-681, Feb. 2001.
Pi-Sunyer, F.X., “Medical Hazards of Obesity,”Annals of Internal Medicine 119(7):655-660, Oct. 1993.

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