Intracorporeally injectable composition for implanting highly co

Details Intracorporeally injectable composition for implanting highly co Intracorporeally injectable composition for implanting highly co

1992-04-15

1994-05-24

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530356, A61L 3300, C08B 3710, C07K 1520, A61K 712

Patent

active

053148746

ABSTRACT:
The present invention provides an intracorporeally injectable non-toxic composition of atelocollagen having an excellent, long-lasting skin swelling effect due to its low viscosity, good fluidity, easy injectability and low antigenicity (without calcification) properties. The composition is prepared by treating an aqueous suspension of atelocollagen with a buffer for physiological conditions. The suspension can have atelocollagen content of 55 to 75 mg/ml, where approximately 20 to 100% by weight of atelocollagen is cross-linked with a polyepoxy compound.

REFERENCES:
patent: 4242291 (1980-12-01), Hughes et al.
patent: 4424208 (1984-01-01), Wallace et al.
patent: 4582640 (1986-04-01), Smestad et al.
patent: 4803075 (1989-02-01), Wallace et al.
patent: 4837285 (1989-06-01), Berg et al.
patent: 5080670 (1992-02-01), Imamura et al.

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