Intracoronary stents containing quinazolinone derivatives

Details Intracoronary stents containing quinazolinone derivatives Intracoronary stents containing quinazolinone derivatives

1999-06-03

2000-12-12

Clardy, S. Mark

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424422, 424424, 424473, 514259, A61K 31505

Patent

active

061594881

ABSTRACT:
The invention provides an intracoronary stent coated with a quinazolinone derivative of formula (I), wherein n is 1 or 2, R.sub.1 is a member of the group consisting of hydrogen, halogen, nitro, benzo, lower alkyl, phenyl and lower alkoxy; R.sub.2 is a member of the group consisting of hydroxy, acetoxy and lower alkoxy, and R3 is a member of the group consisting of hydrogen and lower alkenoxy-carbonyl, and physiologically acceptable salts thereof, for preventing restenosis after angioplasty.

REFERENCES:
patent: 3320124 (1967-05-01), Waletzky et al.
patent: 4340596 (1982-07-01), Schein
patent: 5449678 (1995-09-01), Pines et al.
patent: 5593417 (1997-01-01), Rhodes
patent: 5653727 (1997-08-01), Wiktor
patent: 5891879 (1999-04-01), Nagler et al.
Choi et al., "Halofuginone, A Specific Collagen Type I Inhibitor, Reduces Anastomotic Intimal Hyperplasia." Archives of Surgery, (1995) vol. 130/3: pp. 257-261.
Pines et al., "Halofuginone Hydrobromide." Drugs of the future., (1996) vol. 21/6: pp. 596-599.
Nyska et al., "Topically Applied Halofuginone, An Inhibitor of Collagen Type I Transcription, Reduces Peritendinous Fibrous Adhesions Following Surgery." Connective Tissue Research (1996), vol. 34(2): pp. 97-103.
Granot et al., "Halofuginone: An inhibitor of collagen type I synthesis." Biochimica et Biophysica Acta, (1993) vol. 1156, pp. 107-112.
Lindner et al., "Role of Basic Fibroblast Growth Factor in Vascular Lesion Formation." Circulation Research, (1991), vol. 68(1), pp. 106-113.

Affiliated with

Also associated with

Rating

Intracoronary stents containing quinazolinone derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Intracoronary stents containing quinazolinone derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intracoronary stents containing quinazolinone derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-213809