Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2003-02-18
2008-09-30
Campell, Bruce (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C435S069100, C424S184100
Reexamination Certificate
active
07429385
ABSTRACT:
Methods for obtaining recombinantly produced, C-terminally truncated, E1 and E2 polypeptides from cell lysates are disclosed. The intracellularly expressed truncated molecules display improved biological properties as compared to their secreted counterparts.
REFERENCES:
patent: 5942234 (1999-08-01), Ralston et al.
patent: 6326171 (2001-12-01), Selby et al.
patent: WO 92/08734 (1992-05-01), None
patent: WO9208734 (1992-05-01), None
patent: WO 96/04301 (1996-02-01), None
patent: WO 96/04385 (1996-02-01), None
patent: WO 9604301 (1996-02-01), None
Yan et al. J. Virol. Methods 1994, vol. 49, pp. 343-352.
Hussy et al. Virus Research 1996, vol. 45, pp. 45-57.
Ralston et al. 1993, vol. 67, No. 11, pp. 6753-6761.
Yi et al. Virology 1997, vol. 231, pp. 119-129.
Answers.com . p. 1, published on Aug. 6, 2006.
Choo et al. Proc. Natl. Acad. Sci. USA, 1991, vol. 88, pp. 2451-2455.
Coding JW, Monoclonal antibodies: Principles and Practice. Third Edition, Edited by Coding JW, 1996. See section 4.5 on pp. 56 through p. 57.
Hsu et al., Clinics in Liver disease 1999, vol. 3, pp. 901-915.
Inudoh et al., “Antigenicity of Hepatitis C Virus Envelope Proteins Expressed in Chinese Hamster Ovary Cells,”Vaccine14(17/18):1590-1596 (1996).
Lanford et al., “Analysis of Hepatitis C Virus Capsid, E1, and E2/NS1 Proteins Expressed in Insect Cells,”Virology197:225-235 (1993).
Matsuura et al., “Expression of Processed Envelope Protein of Hepatitis C Virus in Mammalian and Insect Cells,”Journal of Virology66(3):1425-1431 (1992).
Matsuura et al.,Virology205:141-150 (1994).
Nishihara et al., “Secretion and Purification of Hepatitis C Virus NS1 Glycoprotein Produced by Recombinant Baculovirus-Infected Insect Cells,”Gene129:207-214 (1993).
Ralston et al., “Characterization of Hepatitis C Virus Envelope Glycoprotein Complexes Expressed by Recombinant Vaccinia Viruses,”Journal of Virology67(11):6753-6761 (1993).
Spaete et al., “Characterization of the Hepatitis C Virus E2/NS1 Gene Product Expressed in Mammalian Cells,”Virology188:819-830 (1992).
Struyf et al., Eur. J. Immunol. 1998, vol. 28, pp. 1262-1271.
Abrignani Sergio
Chien David
Choo Qui-Lim
Glazer Edward
Houghton Michael
Campell Bruce
Li Bao Qun
Novartis Vaccines & Diagnostics
Robins & Pasternak LLP
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