Intrabodies with defined framework that is stable in a...

Details Intrabodies with defined framework that is stable in a... Intrabodies with defined framework that is stable in a...

2007-08-21

2007-08-21

Wessendorf, T. D. (Department: 1639)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S006120, C435S091500, C435S091500, C435S091500, C530S388100, C530S387100, C530S350000

Reexamination Certificate

active

10169179

ABSTRACT:
A method for the isolation of CDRs in a defined framework that is stable and soluble in reducing environment is described as well as thus obtainable scFv. Starting from such scFv with defined framework a scFv library can be generated wherein the framework is conserved while at least one complementary determining region (CDR) is randomized. Such library, e.g. in yeast cells, is suitable for screening for antibody/CDR-interactions or for screening for antibodies.

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