Intra-tumoral administration of IL-12 encoding nucleic acid...

Details Intra-tumoral administration of IL-12 encoding nucleic acid... Intra-tumoral administration of IL-12 encoding nucleic acid...

2006-11-28

2006-11-28

Li, Q. Janice (Department: 1633)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S320100, C435S455000, C536S023500

Reexamination Certificate

active

07141550

ABSTRACT:
Described is the use of a nucleic acid molecule encoding an IL-12 polypeptide for the preparation of a pharmaceutical composition for the treatment of a tumor, wherein the pharmaceutical composition is for intra-tumoral administration.

REFERENCES:
patent: WO 01/52874 (2001-07-01), None
Addison et al, Gene Ther 1998;5:1400-9.
Tuting et al, Cancer Gene Ther. Jan.-Feb. 1999;6:73-80.
Lipford et al, Eur J Immunol. Sep. 1997;27:2340-4.
Gilbert et al, STEP Perspect 1998 Winter;98:15-7.
Mendiratta, SK. et al., “Intratumoral delivery of IL-12 gene by polyvinyl polymeric vector system to murine renal and colon carcinoma results in potent antitumor immunity”Gene Therapy, vol. 6, No. 5:833-839 (1999).
Asselin-Paturel, C. et al., “Transfer of the murine interleukin-12 gene in vivo by a Semliki Forest virus vector induces B16 tumor regression through inhibition of tumor blood vessel formation monitored by Doppler ultrasonography”Gene Therapy, vol. 6, No. 4:606-615 (1999).
Budryk, M. et al., “Direct transfer of IL-12 gene into growing Renca tumors”ACTA Biochimica Polonica, 47:385-391 (2000) (Abstract).
Moriyama, M. et al., “Mechanical properties of SiNxCyceramic films prepared by plasma CVD”Journal of Materials Science, 5:1287-1294 (1991).
Yang, J-P. et al., “Direct gene transfer to mouse melanoma by intratumor injection of free DNA”Gene Therapy, vol. 3, No. 3:542-548 (1996) (Abstract).
Witold, L. et al., “Antitumor effects of the combination immunotherapy with interleukin-12 and tumor necrosis factor alpha in mice”Cancer Immunology Immunotherapy, vol. 45, No. 2:100-108 (1997) (Abstract).
Nestle, F. O. et al., “Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells”Nature Medicine, 4:328-332 (1998) (Abstract).
Chu, R. S. et al., “CpG oligodeoxynucleotides act as adjuvants that switch on T Helper 1 (Th1) Immunity”,Journal of Experimental Medicinevol. 186, No. 10:1623-1631 (1997).
Yasunori, E. et al., “Interleukin-12 (IL-12) enhances antitumor activity of chemotherapy and radiotherapy in murine models.”Proceedings of the American Association for Cancer Research Annual. vol. 36:480 (1995) (Abstract).
Mullins. D W et al. “Interleukin-12 overcomes paclitaxel-mediated suppression of T-cell proliferation”Immunopharmacology and Immunotoxicology, vol. 20, No. 4:473-492 (1998) (Abstract).
Mendiratta, S. K. et al, “Combination of interleukin 12 and interferon alpha gene therapy induces a synergistic antitumor response against colon and renal cell carcinoma”Human Gene Therapy, vol. 11, No. 13:1851-1862 (2000) (Abstract).
Schultz, J. et al., “Induction of long-lasting cytokine effect by injection of IL-12 encoding plasmid DNA”Human Genetics, 1557-1565 (2000) (Abstract).
Schultz J. et al., “Long-lasting anti-metastatic efficiency of interleukin 12-encoding plasmid DNA”Human Gene Therapy, vol. 10, No. 3:407-417 (1999) (Abstract).
Mumper, R. J., “Protective interactive noncondensing (PINC) polymers for enhanced plasmid distribution and expression in rat skeletal muscle”Journal of Controlled Release, 52:191-203 (1998).
Luo, D. et al., “Synthetic DNA delivery systems”Nature Biotechnology, 18:33-37 (1999).
Kircheis, R. et al., “Polycation-based DNA complexes for tumor-targeted gene delivery in vivo”The Journal of Gene Medicine, 1:111-120 (1999).
Mumper, R. J. et al., “Polyvinyl derivatives as novel interactive polymers for controlled gene delivery to muscle”Pharmaceutical Research, vol. 13, No. 5:701-709 (1996).
Confirmation of receipt of publication date for vol. 47, No. 2/2000 ofActa Biochimica Polnica.
Results of Clinical Trials using intra-tumoral administration of naked DNA encoding IL-12, as submitted by Dr. Karin Mölling in PCT/EPO1/00363 on Feb. 2, 2002.
Gao, P. et al., “TGF beta 1 on murine tumor growth following direct intratumoral injection of plasmid DNA”Zhonghua Zhong Liu Za Zhi, vol. 19, No. 2:93-5 (1997).
Goto, T. et al., “Highly effective electro-gene therapy of solid tumor by using an expression plasmid for the herpes simplex virus thymidine kinase gene”,Procedings of National Academy of Science U.S.A., vol. 97, No. 1:354-9. (2000).
Hauses, M. et al., “Gene therapy and gastrointestinal cancer: concepts and clinical facts”, vol. 384, No. 5:479-88. (1999) (Abstract).
Hauses, M. et al., “Gene therapy and gastrointestinal cancer: concepts and clinical facts”, vol. 384, No. 5:479-88. (1999).
Kouraklis, G. et al., “Progress in cancer gene therapy”, Acta Oncology, vol. 38, No. 6:675-83 (1999).
Sussman et al., “The structural basis for molecular recognition by the vitamin B12RNA aptamer”Nature Structural Biology, 7: 53-57 (2000).
Okazawa et al., “In vitro selection of hematoporphyrin binding DNA aptamers”Bioorganic&Medicinal Chemistry Letters, 10: 2653-56 (2000).
Romig et al., “Aptamer affinity chromatography: combinatorial chemistry applied to protein purification”Journal of Chromatography B, 731: 275-284 (1999).
Sun, “Technology evaluation: SELEX, Gilead Sciences Inc”Current Opinion in Molecular Therapeutics, 2: 100-105 (2000).

Affiliated with

Also associated with

Rating

Intra-tumoral administration of IL-12 encoding nucleic acid... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Intra-tumoral administration of IL-12 encoding nucleic acid..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intra-tumoral administration of IL-12 encoding nucleic acid... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3700978