Intra-respiratory vaccine for prevention of Bordetella bronchise

Details Intra-respiratory vaccine for prevention of Bordetella bronchise Intra-respiratory vaccine for prevention of Bordetella bronchise

1978-12-07

1980-09-30

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

A61K 3902

Patent

active

042255830

ABSTRACT:
A vaccine for animals subject to Bordetella bronchiseptica infection comprises an aqueous suspension of viable cells of the modified Bordetella bronchiseptica previously identified as strain 55 and now further identified as ATCC strain No. 31437. Strain 55 is not merely attenuated and avirulent but has been modified so that it will colonize the respiratory mucosa of animals for only a limited time before it is cleared, causing no adverse effect on the animals. During the limited period of growth on the respiratory mucosa, however, strain 55 is capable of inducing local resistance to B. bronchiseptica infection. Swine are thereby protected against atrophic rhinitis and turbinate atrophy and dogs against tracheobronchitis (kennel cough).

REFERENCES:
patent: 3127318 (1964-03-01), Eversole et al.
patent: 3462526 (1969-08-01), Ratuld et al.
patent: 3594471 (1971-07-01), Hertzberger et al.
patent: 3608066 (1971-09-01), Illartein
patent: 3755557 (1973-08-01), Jacobs
patent: 3873691 (1975-03-01), Kasuga et al.
patent: 3950512 (1976-04-01), Emery et al.
patent: 4016253 (1977-04-01), Switzer et al.
Shimizu Infect. Immun., 22(2):318-321, Nov. 1978, "Prophylaxis of Bordetella Bronchiseptica Infection in Guinea Pigs by Intranasal Vaccination with Live Strain, TS-S34."

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