Intra-operative molecular imaging

Details Intra-operative molecular imaging Intra-operative molecular imaging

2007-06-12

2011-12-13

Le, Long V. (Department: 3737)

Surgery

Diagnostic testing

Detecting nuclear, electromagnetic, or ultrasonic radiation

C424S009600

Reexamination Certificate

active

08078264

ABSTRACT:
A system for imaging an abnormal cell and or diseased tissue after topical application of a near infrared protease-specific probe is disclosed. The system includes a protease-specific near infrared (NIRF) imaging probe, means for topically administering the protease-specific probe to a diseased tissue and an imaging device capable of detecting the interaction between the protease-specific NIRF imaging probe and the diseased tissue. A method and surgical procedure are also disclosed.

REFERENCES:
patent: 7977058 (2011-07-01), Low
Weissleder et al., “In vivo imaging of tumors with protease-activated near-infrared fluorescent probes”, Nature Biotechnology, vol. 17, Apr. 1999.
Veiseh et al., Turn or Paint: A Chlorotoxin: Cy5.5 Bioconjugate . . . ,Cancer Res 2007; 67:(14). Jul. 15, 2007, pp. 6882-6888, www.aacrjournals.org (I2007 Amer. Assoc. for Cancer Research.

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