Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1995-03-23
1998-05-05
Loring, Susan A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
530350, 530825, C07K 14245, C07K 1400, C07K 1424
Patent
active
057472939
ABSTRACT:
The invention is related to antibodies, particularly monoclonal antibodies, which recognize particularly epitopes of the intimin protein of enteropathogenic E. coli and enterohemorrhagic E. coli, methods of detecting such E. coli by use of these antibodies, and kits containing these antibodies for diagnosis.
REFERENCES:
Jerse, A., et al., "A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells," Proc. Natl. Acad. Sci. U.S.A., vol. 87, pp. 7839-7843, (Oct. 1990).
Yu, J. and Kaper, J.B., "Cloning and characterization of the eae gene of enterohaemorrhagic Escherichia coli 0157:H7," Molecular Microbiology 6(3), pp. 411-417, (1992).
Frankel, G., et al., "Characterization of the C-Terminal Domains of Intimin-Like Proteins of Enteropathogenic and Enterohemorrhagic Escherichia coli, Citrobacter freundii, and Hafnia alvei," Infection and Immunity, vol. 62, No. 5, pp. 1835-1842, (May 1994).
Donnenberg, M. S., et al., "Role of the eaeA Gene in Experimental Enteropathogenic Escherichia coli Infection," J. Clin. Invest., vol 92, pp. 1412-1417, (Sep. 1993).
Dougan Gordon
Frankel Gad
Imperial College of Science Technology & Medicine
Loring Susan A.
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