Intestinal oncofetal gene

Details Intestinal oncofetal gene Intestinal oncofetal gene

1988-08-31

1992-12-15

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 935 9, C12N 1512, C07H 2102, C07H 2104

Patent

active

051718502

ABSTRACT:
The preparation and use of polynucleotides and polypeptides corresponding to a novel gene expressed in fetal intestinal endoderm cells and the corresponding gene product, respectively, are disclosed. Expression of the gene, designated the intestinal oncofetal gene, is associated with neoplastic transformation in non-fetal intestinal cells other than adult crypt cells.
Clone OCI-5 was deposited at the American Type Culture Collection, 12301 Parklawn Drive, Rocksville, Maryland 20852, U.S.A., on Aug. 18, 1988, and granted accession No. 40481.

REFERENCES:
Filmus et al. Molecular and Cellular Biology 8(10):4243-4249, 1988.
Chemical Abstracts, vol. 107, No. 1, 1987, Abstract No. 1754p, Julien et al. Mol. Brain Res. vol. 1(3):243-250, 1986.
Chemical Abstracts, vol. 111, No. 3, 1989, Abstract No. 18541x, Filmus et al., Molecular and Cellular Biology, vol. 8, No. 10, pp. 4243-4249.
Quaroni and Isselbacher (1981) J. Natl. Cancer, Inst. 67:1353-1362.

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