Interstrand crosslinking agents for DNA and compounds therefor

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S259100, C514S283000, C514S410000, C548S427000, C548S428000, C548S433000

Reexamination Certificate

active

06946455

ABSTRACT:
Compounds represented by the general formula (I): which two DNA strands can be interstrand-crossliked:in-line-formulae description="In-line Formulae" end="lead"?A-L-B-X-B-L-A  (I)in-line-formulae description="In-line Formulae" end="tail"?wherein B represents a chemical structure capable of recognizing the nucleotide sequence of DNA; A represents a chemical structure capable of binding to one of the bases of DNA; L represents a linker by which the chemical structures of A and B can be linked to each other; X represents a spacer by which the A-L-B components can be linked to each other. A method of interstrand-crosslinking DNA by using these compounds; and medicinal compositions containing interstarand-crosslinking agents of DNA.

REFERENCES:
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patent: WO 00/15641 (2000-03-01), None
patent: WO 01/36677 (2001-05-01), None
Lee et al. J. Am. Chem. Soc. 1997, 119, 3434-3442.
T. Bando et al.,Journal of the American Chemical Society,123(21):5158-5159 (2001).

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