Interstitial prostatism model animal

Details Interstitial prostatism model animal Interstitial prostatism model animal

2002-05-08

2008-08-26

Paras, Jr., Peter (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S008000, C800S009000

Reexamination Certificate

active

07417175

ABSTRACT:
The present invention provides an animal model for prostatic stromal hyperplasia, and a method for screening for a substance effective for preventing/treating human benign prostatic hyperplasia using the animal model. The animal model for prostatic stromal hyperplasia is produced by implanting the fetal urogenital sinus of a non-human animal under the skin or beneath the prostatic capsule of a non-human animal belonging to the species of the same as or different from the animal. A substance effective for preventing/treating human benign prostatic hyperplasia can be screened by administering a test substance to the animal model and measuring the preventive or therapeutic effect of the test substance upon the implanted tissue (fetal urogenital sinus or tissue derived therefrom).

REFERENCES:
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Chung et al. (1984) Tissue Interactions and Prostatic Growth. I. Induction of Adult Mouse Prostatic Hyperplasia by Fetal Urogenital Sinus Implants. 31:155-163.
Goto et al. (2000) Gene Therapy and Transplantation. Transplantation. vol. 69, pp. 1995-1999.
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Supplementary Partial European Search Report from corresponding European patent application serial No. EP 02 76 9216.

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