Interstitial administration of perfluorochemical emulsions for r

Details Interstitial administration of perfluorochemical emulsions for r Interstitial administration of perfluorochemical emulsions for r

1987-02-20

1988-11-01

Rosenbaum, C. Fred

Surgery

Means for introducing or removing material from body for...

Infrared, visible light, ultraviolet, x-ray or electrical...

604 51, 128362, 128804, 514 34, 600 1, A61N 130

Patent

active

047816767

ABSTRACT:
A method is set forth for treatment of hypoxic tumors by interstitial injection of oxygen bearing fluorocarbon emulsions directly into the hypoxic zone of the tumor followed by radiation treatment.

REFERENCES:
patent: 4325772 (1982-04-01), Geyer et al.
patent: 4558690 (1985-12-01), Joyce
patent: 4686085 (1987-08-01), Osterholm
patent: 4742050 (1988-05-01), Yuhos et al.
Martin et al; "Enhancement of Tumor Radiation Response by the Combination of a Perfluorochemical Emulsion and Hyperbaric Oxygen"; 5-87; Int. J. Radiation Oncology Biology Physics 13:5, pp. 747-751.
King et al; "Peripheral Vascular Responses to Fluorocarbon Administration", Microvascular Research; 33, 183-193 (1987).
T. Kokunai et al; "Effect of Perfluorochemicals on BLNU Chemotherapy in Rat Brain Tumor Model", Brain & Nerve 1982, 34(6), 609-615.
Author (Rockwell/Mate/Irvin & Nierenburg), Date-2/6/86, Title (Reactions of Tumors & Normal Tissues in Mice to Irradiation in the Presence and Absense of a Perfluorochemical Emulsion.
Author (McIntosh), Date-12/11/86, Title (Process for Treating Metastasis of Cancerous Tumors).
Author (Yuhus), Date-8/10/83, Title (Perfluorocarbon Emulsions & Their Preparation & Use in Therapy).
Author (Rockwell), Date-8/17/84, Title (Use of a Perfluorochemical Emulsion to Improve Oxygenation in a Solid Tumor).
Author (Brown), Date-1984, Title (Sensitizers & Protectors to Radiation & Chemotherapeutic Drugs).
Author (Lustig & McIntosh), Date-1986, Title (Fluosol.sup.R -DA in Radiation Therapy).

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