Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-02-28
2006-02-28
Benzion, Gary (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100
Reexamination Certificate
active
07005267
ABSTRACT:
Disclosed herein are isolated nucleic acid molecules that may be used as an internal positive controls in probe-based nucleic acid assays such as TaqMan® based assays. Also disclosed are probes comprising the isolated nucleic acid molecule of the present invention. The probes may comprise a reporter molecule and a quencher molecule. Also disclosed are assays which comprise using the probe of the present invention. The probes may be used to distinguish false negative results from true negative results in assays for a target nucleic acid molecule. The probe may be used in conjunction with probe-based nucleic acid assays for the detection of an organism such as one belonging toBacillus, Mycobacterium, Francisella, Brucella, Clostridium, Yersinia, Variola, Orthopox, or Burkholderia.
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Notification of Transmittal of the International Search Report or the Declaration (Form PCT/ISA/220) issued for PCT/US03/06347.
International Search Report (Form PCT/ISA/210) issued for PCT/US03/06347.
Courtney, et al. (1999) “Development of Internal Controls for Probe-Based Nucleic Acid Diagnostic Assays” Anal. Biochem. 270(2):249-256.
Hartman, et al. (2005) “Development of a Novel Internal Positive Control for Taqman Based Assays” Mol. Cell. Probes 19:51-59.
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European Supplementary Search Report mailed Jul. 18, 2005.
Hartman Laurie J.
Norwood, Jr. David A.
Arwine Elizabeth
Benzion Gary
The United States of America as represented by the Secretary of
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