Internal deletion mutants of soluble T4(CD4)

Details Internal deletion mutants of soluble T4(CD4) Internal deletion mutants of soluble T4(CD4)

1992-02-05

1995-06-06

Elliott, George C.

Chemistry: molecular biology and microbiology

Vector, per se

4351723, 435 694, 435 696, 53038835, 536 231, 4241881, 4242081, C12N 1500, A61K 3900, C07K 300

Patent

active

054222745

ABSTRACT:
This invention provides a therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein which comprises a polypeptide. In one embodiment of the invention, the amino acid sequence of the polypeptide has the amino acid sequence shown in FIG. 6 from about +1 to about +185 fused to the amino acid sequence from about +353 to about +371. In another embodiment of the invention, the amino acid sequence of the polypeptide has the amino acid sequence shown in FIG. 6 from about +1 to about +106 fused to the amino acid sequence from about +353 to about +371. In yet a further embodiment of the invention, the amino acid sequence of the polypeptide has the amino acid sequence shown in FIG. 6 from about +1 to about +185.
This invention also provides a method for treating a subject infected with a human immunodeficiency virus. The method treats the subject with an effective amount of a pharmaceutical composition having an effective amount of a therapeutic agent of the invention and a pharmaceutically acceptable carrier.

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