Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-07-12
1996-06-04
Rizzo, Nicholas
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548550, 548541, C07D20700
Patent
active
055234151
ABSTRACT:
An antibacterial aminooxypyrrolidinylthiocarbapenem I, its production from the corresponding carbapenem V and thiol VI, its pharmaceutical formulation, and its use for combating bacteria are presented. ##STR1## (wherein R is optionally substituted amino; R.sup.1 is hydrogen or 1C to 5C alkyl; R.sup.2 is hydrogen or a conventional hydroxy protective group; R.sup.3 is hydrogen or an imino protective group or imino substituent; R.sup.4 is 1C to 5C alkylene; and R.sup.5 is hydrogen or a conventional carboxy protective group; X is a leaving group; R.sup.6 is hydrogen or a thiol protective group; and wavy lines each shows a bond in R or S configuration).
REFERENCES:
patent: 4251541 (1981-02-01), Walsh et al.
patent: 4983596 (1991-01-01), Murata et al.
patent: 5093328 (1992-03-01), Sunagawa et al.
Chemical Abstracts vol. 18(23)233767(a) 1994.
Chemical Abstracts vol. 118:233767 (1983).
Chemical Abstracts vol. 118 233767(1993).
Kii Makoto
Sendo Yuji
Rizzo Nicholas
Shionogi Seiyaku Kabushiki Kaisha
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