Intermediates useful in the synthesis of pyrazolopyrimidinone an

Details Intermediates useful in the synthesis of pyrazolopyrimidinone an Intermediates useful in the synthesis of pyrazolopyrimidinone an

1994-06-24

1998-02-17

Gupta, Yogendra N.

Organic compounds -- part of the class 532-570 series

Organic compounds

Pteroyl per se or having -c-, wherein x is chalcogen, bonded...

544118, C07D48704

Patent

active

057192839

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 is H, C.sub.1 -C.sub.3 alkyl, C.sub.3 -C.sub.5 cycloalkyl or C.sub.1 -C.sub.3 perfluoroalkyl;
R.sup.2 is H, C.sub.1 -C.sub.6 alkyl optionally substituted by OH, C.sub.1 -C.sub.3 alkoxy or C.sub.3 -C.sub.6 cycloalkyl, or C.sub.1 -C.sub.3 perfluoroalkyl;
R.sup.3 is H, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.1 -C.sub.6 perfluoroalkyl or (C.sub.3 -C.sub.6 cycloalkyl)C.sub.1 -C.sub.6 alkyl;
and Y is chloro, bromo, or fluoro.
The above compounds are intermediates useful in the synthesis of certain pyrazolopyrimidinones which inhibit cyclic guanosine 3', 5'-monophosphate phosphodiesterase.

REFERENCES:
patent: 4052390 (1977-10-01), Broughton et al.
patent: 4167568 (1979-09-01), Knowles et al.
patent: 4666908 (1987-05-01), Hamilton
patent: 5272147 (1993-12-01), Bell et al.
Hamilton et al., J. Med. Chem., 30 (1), 91-96, (1987).

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