Intermediates useful in the synthesis of optically active m-acyl

Details Intermediates useful in the synthesis of optically active m-acyl Intermediates useful in the synthesis of optically active m-acyl

1977-05-09

1979-06-12

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

260307FA, 260404, C07D49810

Patent

active

041580052

ABSTRACT:
Optically and therapeutically active compounds of the formula: ##STR1## wherein R represents a member selected from the group consisting of a straight or branched alkyl group of from one to twenty carbon atoms (C.sub.1 -C.sub.5 being preferred), an ethoxycarbonyl group, a benzyloxycarbonyl group, a phenyl group, an ##STR2## WHEREIN R is as defined above and R.sub.3 is a member selected from the group consisting of a hydrogen atom, a methyl group and a phenyl group, and a 2-, 3-, or 4-pyridyl group, or the HX salts thereof, wherein X represents a pharmaceutically acceptable acid addition salt anion, are prepared optically active m-hydroxy-.alpha.-[methylamino)methyl]benzyl alcohol (phenylephrine).
The compounds prepared by the process of this invention find therapeutic application to warm-blooded animals (e.g., humans) in the management of asthma, nasal congestion and as decongestants, vasoconstrictors, mydriatic agents, and anti-glaucomatous agents in the practice of ophthalmology.
Upon administration, these compounds will enzymatically "cleave," thus releasing optically active phenylephrine (m-hydroxy-.alpha.-[(methylamino)methyl]benzyl alcohol, the therapeutically active moiety thereof.

REFERENCES:
patent: 3429892 (1969-02-01), Loev
patent: 3431272 (1969-03-01), Loev
patent: 3431273 (1969-03-01), Loev
patent: 3481942 (1969-12-01), Loev

Affiliated with

Also associated with

Rating

Intermediates useful in the synthesis of optically active m-acyl does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Intermediates useful in the synthesis of optically active m-acyl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intermediates useful in the synthesis of optically active m-acyl will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1109332