Intermediates useful in the preparation of 3,4-dihydro-4-oxothie

Details Intermediates useful in the preparation of 3,4-dihydro-4-oxothie Intermediates useful in the preparation of 3,4-dihydro-4-oxothie

1985-12-23

1987-10-20

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544250, 549 68, C07D49504

Patent

active

047015284

ABSTRACT:
There are disclosed compounds of Formulas I and II: ##STR1## wherein R.sup.1 and R.sup.2 may be hydrogen, lower alkyl having from 1 to 8 carbon atoms, lower alkenyl having from 3 to 6 carbon atoms, lower alkoxy having from 1 to 6 carbon atoms, hydroxy, nitro, amino, halo including chlorine, bromine, iodine, and fluorine, phenyl, alkanoyl having from 2 to 6 carbon atoms or they are bonded to one another to form a cycloalkene ring fused to the thiophene ring and having a total of from 5 to 7 annular ring carbon atoms, and R.sup.3 is an aliphatic or an aromatic group such as lower alkyl, e.g., methyl or ethyl. Such compounds are useful as intermediates in the production of tiprinast and related compounds.
There is also disclosed a process for the regioselective synthesis of a compound of Formula I wherein R.sup.1 is CH.sub.3 and R.sup.2 is (CH.sub.3).sub.2 CHCH.sub.2 which comprises reacting a mixture of compounds of the following formulas: ##STR2## and ##STR3## with trichloroacetonitrile under acidic conditions.

REFERENCES:
patent: 4054656 (1977-10-01), Temple, Jr.
patent: 4159377 (1979-06-01), Temple, Jr.
von Walter Ried and Roland Giesse, Liebigs Ann. Chem. 713, 143-148 (1968).
Temple, et al., Journal of Medicinal Chemistry, 1979, vol. 22, No. 5, pp. 505-510.
Gewald, et al., Chem. Ber., 99, (1966), pp. 94-100.

Affiliated with

Also associated with

Rating

Intermediates useful in the preparation of 3,4-dihydro-4-oxothie does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Intermediates useful in the preparation of 3,4-dihydro-4-oxothie, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intermediates useful in the preparation of 3,4-dihydro-4-oxothie will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1613117