Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-05-31
1997-12-23
Dentz, Bernard
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D491052
Patent
active
057009392
ABSTRACT:
The present invention provides a process for the asymmetric synthesis of camptothecin analogues as well as novel chemical intermediates of Formula I, II, and III. In general, the present process comprises conversion of a cis dioxolanone, having the same desired absolute configuration as the desired camptothecin analogue, to a compound of Formula I, II, or III, which compound is then converted to the desired camptothecin analogue. ##STR1##
REFERENCES:
patent: 5247089 (1993-09-01), Comins et al.
Dentz Bernard
Lentz Edward T.
SmithKline Beecham Corporation
Stercho, Ph.D. Yuriy P.
Venetianer Stephen A.
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