Intermediates to 4-amino- hexahydrobenz (cd) indoles and process

Details Intermediates to 4-amino- hexahydrobenz (cd) indoles and process Intermediates to 4-amino- hexahydrobenz (cd) indoles and process

1995-09-12

1996-09-24

Powers, Fiona T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D48702

Patent

active

055592457

ABSTRACT:
New intermediates, and processes therefor, provide an efficient method for deriving 4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles, which are themselves intermediates to useful CNS agents, from the Kornfeld-Woodward ketone and like compounds. Preferred embodiments provide means for the preparation of substantially pure enantiomers of the desired 4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indole.

REFERENCES:
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patent: 3575989 (1971-04-01), Razdan et al.
patent: 4098895 (1978-07-01), Hubele et al.
patent: 4110339 (1978-08-01), Bach et al.
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patent: 4576959 (1986-03-01), Flaugh
patent: 4745126 (1988-05-01), Leander
patent: 4914214 (1990-04-01), Vincent et al.
Nedelec et al., J. Med. Chem., 26, 522-527 (1983).
Freeman et al., Synthesis, Dec. 1974, pp. 894-895.
Mitsunobu, Synthesis, Jan. 1981, pp. 1-28.
Martinelli, et al., Tet. Lett., 31(52), 7579 (1990).

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