Intermediates in the total synthesis employing substituted isoxa

Details Intermediates in the total synthesis employing substituted isoxa Intermediates in the total synthesis employing substituted isoxa

1976-06-14

1978-03-21

Love, Ethel G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260290H, 260307H, 260307R, 2603268, 260327M, 2603405AS, 2603407, 2603453, 2603973, 260586F, C07D31772, C07D49310

Patent

active

040803341

ABSTRACT:
The intermediates and processes of this invention provide a new synthetic route for the preparation of pharmaceutically valuable 19-norsteroids. Further, the intermediates and processes of the invention provide a route for the preparation of pharmaceutically valuable estrones. The present invention provides a facile total synthesis of 19.beta.-alkyl-C/D-trans-steroidal materials. This desirable result is obtained via a unique asymmetric induction followed by subsequent stereo-specific reaction steps. As a precursor to the steroidal Ring A, a 3,5-disubstituted-4-isoxazolylmethylene group is employed in this synthesis.

REFERENCES:
patent: 3985771 (1976-10-01), Saucy et al.

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