Intermediates in the synthesis of novel (1-phenyl-1-heterocyclyl

Details Intermediates in the synthesis of novel (1-phenyl-1-heterocyclyl Intermediates in the synthesis of novel (1-phenyl-1-heterocyclyl

1995-06-02

1998-12-15

MacMillan, Keith D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5462744, 5462747, 5462751, 548120, 548182, 548186, 548187, 548200, 548202, 548203, 548204, 548205, 548215, 548225, 548226, 548227, 548228, 548229, 548230, 548232, 548236, 548100, 548235, 514365, 514359, 514374, C07D20330, C07D22730, A61K 3142, A61K 31425

Patent

active

058499210

ABSTRACT:
Angiotensin-II antagonists of the formula ##STR1## wherein R.sub.1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R.sub.2 is, inter alia, optionally substituted butanesultam-1-yl, imidazol-4-yl, and tetrahydobenzimidazol-2-yl; R.sub.3 is, inter alia, lower alkyl; and, R.sub.4 is an acidic group, such as carboxyl or tetrazolyl. An exemplary compound is: zimidazol-1-yl)-methyl!-biphenyl-2-carboxylic acid.

REFERENCES:
patent: 5385921 (1995-01-01), Boar et al.
Chemical Abtracts AN 74:125538, Maier et al., Jan. 1974.
Chemical Abstracts AN 69:10391, Crousier et al., Jan. 1969.
Chemical Abstracts AN 1984:510794, Rahman et al., Jan. 1984.
Chemical Abtracts AN 1990:515314, Imura et al., Mar. 30.
Patel et al, J. Geriatric Psychiatry and Neurology, vol. 8, pp. 81-95, Apr. 1995.
Chemical Abstracts AN 1987:629837, Gill et al.
Dondoni et al., "Synthesis of (Trimethylsilyl)thiazoles and Reactions with Carbonyl Compounds. Selectivity Aspects and Synthetic Utility," J. Org. Chem. vol. 53, pp. 1748-1761 (1988).

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