Intermediates in the synthesis of (.+-.)-camptothecin and relate

Details Intermediates in the synthesis of (.+-.)-camptothecin and relate Intermediates in the synthesis of (.+-.)-camptothecin and relate

1997-11-14

2000-03-07

Huang, Evelyn Mei

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546300, C07D21364

Patent

active

060342439

ABSTRACT:
The present invention provides a short, convergent total synthesis of novel intermediates in the synthesis of (.+-.)-camptothecin and related compounds. The present synthesis scheme includes a novel 4+1 radical annulation followed by another cyclization to simultaneously assemble rings B and C of the camptothecin compound. The present invention also provides novel chemical intermediates for such 4+1 radical annulations.

REFERENCES:
Curran DP and Liu H. J. Am. Chem. Soc. 114, pp. 5863-5864, Jul. 1, 1992.

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